alexa Visualization of Different Morphological Structures within Pigmented Melanocytic Skin Lesion Melanoma: Case Studies | Open Access Journals
ISSN: 2376-0427
Dermatology and Dermatologic Diseases
Like us on:

Previously: Journal of Pigmentary Disorders

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Visualization of Different Morphological Structures within Pigmented Melanocytic Skin Lesion Melanoma: Case Studies

Irdina Drljevic1* and Kenan Drljevic2

1Clinic of Dermatology and Venereology, Clinical Centre of the University of Sarajevo, Bolnička, Sarajevo, Bosnia and Herzegovina, Balkans

2Obstetrics and Gynaecology Department, General Hospital, Kranjčevićeva, Sarajevo, Bosnia and Herzegovina, Balkans

*Corresponding Author:
Irdina Drljevic
Clinic of Dermatology and Venereology
Clinical Centre of the University of Sarajevo
Bolnička 25, 71000 Sarajevo, Bosnia and Herzegovina
Balkans
Tel: +387 33 297-000
E-mail: [email protected]

Received date: March 31, 2017; Accepted date: April 17, 2017; Published date: April 24, 2017

Citation: Drljevic I, Drljevic K (2017) Visualization of Different Morphological Structures within Pigmented Melanocytic Skin Lesion Melanoma: Case Studies. J Pigment Disord 4:262. doi:10.4172/2376-0427.1000262

Copyright: © 2017 Drljevic I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Dermatology and Dermatologic Diseases

Abstract

Dermoscopy is valid, non-invasive technique for the visualization of different morphological structures within pigmented melanocytic skin lesion. In clinical practice, positive personal history is considered to be as an indication of increased melanoma risk. The thickness of melanoma (Breslow Index) is the most important independent predicting factor of survival for stage I patients. We aimed to present two cases of head-melanoma and discuss prominent clinical and dermoscopic features across the spectrum of “hidden-melanoma” and differential diagnosis.

Keywords

Skin; Head; Melanoma; Dermoscopy; Differential diagnosis

Introduction

Melanoma is a malignant tumor of melanocytes, whose incidence has been increasing all over the world. Most authors believe that there is still no specific diagnostic criterion enabling an unambiguous clinical diagnosis of melanoma [1]. Most often it is found on skin, which should direct doctors and patients to early recognition and detection of the disease [2]. Scalp melanoma is included in the group of head and neck melanomas, which make approximately 10-20% of all primary skin melanomas [3]. It is defined as a tumor usually located in the area of the head covered with hair (hair-bearing area melanoma) and it is also called “hidden” melanoma or “invisible killer” [4]. Lentigo malign melanoma is the most frequent histological subtype of melanoma in elderly women, whereas superficially spreading and nodular melanomas are found in the scalp area in men, mostly older than 50 [5].

Case Study I

A 45 year old patient presented to a dermatologist for occasional bleeding of a mole in the right retroauricular region (as shown in Figure 1). He had noticed first changes of color and size of the mole a year before. His mother’s brother had had a similar tumor operated a few years ago. Before the age of 20 he had had several sunburns.

At the moment of the examination a slightly elevated macula measuring 16 × 14 mm could be seen, it was dark brown and black, with irregular contours and wet. Dermatoscopic examination was done with the digital dermatoscope MoleMax II and under twenty times magnification the following dermatoscopic structures were noticed: atypical pigment network, irregular streaks, homogeneous area, irregular dots and globules, blue-white veil (Figure 2). An operative treatment and extirpation of the first sentinel lymph node were recommended. Histological testing by standard hematoxylin-eosin (HE) technique showed that it was a superficial spreading melanoma with a phase of vertical growth and multifocally present ulcerations of epidermis.

pigmentary-disorders-spreading-melanoma

Figure 1: Superficial spreading melanoma.

pigmentary-disorders-Dermoscopy-SSM

Figure 2: Dermoscopy of SSM.

The tumor reached papillary and reticular dermis, and dense lympho-plasmocytic inflammatory response was found in the infiltrative edge. Sub epidermal individual atypical melanocytes in lymph nodes were noted in the sample, and SNL, i.e., extirpation of the first sentinel lymph node was recommended. Conclusion: Superficial spreading melanoma Clark 4, level pT3b, Breslow 2,6 mm, with invasion of lymph nodes present.

Case Study II

A 74 year old patient asked for dermatological examination because of injury of a mole in the hairy part of his head and occasional bleeding. Anamnesis on the duration of the disease is unreliable. Photo-type 1. Before the age of 20 he had had several sunburns. At the moment of the examination a 10 mm tumor nodule of grey-pink color was noticed in the right parietal region with a slightly elevated dark macula of irregular contours (Figure 3).

pigmentary-disorders-Nodular-melanoma

Figure 3: Nodular melanoma (NM).

The tumor nodule easily bled on palpation. Dermatoscopic examination showed the following structures: homogeneous area, irregular dots/globules and irregular vessels vs. “poppy field” sign in Figure 4.

pigmentary-disorders-Dermoscopy-nodular

Figure 4: Dermoscopy of nodular melanoma.

Nodular melanoma from pre-existing epidermal-dermal nevus, Clark 4, level pT4b, Breslow 10 mm.

Discussion

Numerous risk factors for appearance of melanoma have been identified up to date, but exposure to the sun UV-radiation is the most significant. Recent studies have shown that head and neck melanoma occurs more frequently in persons who were chronically exposed to sunlight during their life, whereas melanoma of lower legs and upper back and chest are linked to intermittent exposure to UV-rays, most often as a result of visiting “sunny countries” or recreational exposure [6]. Persons with red or blond hair, light eyes, a higher number of so called common nevi or one and/or more dysplastic nevi including a positive personal and/or family history of melanoma, have a higher risk for occurrence of melanoma. Studies have shown that patients with surgically treated melanoma develop another primary skin melanoma in 5-10% of cases [7].

Dermatoscopy (epilumenescence microscopy, dermoscopy) is in vivo non-invasive and painless diagnostic method used to show skin structure which cannot be seen by naked eyes: epidermis, dermoepidermal junction and papillary dermis [8]. Its basic use includes diagnostics of pigmented skin tumors, primarily melanocytic, but also non-melanocytic ones. Differentiation between these two types is the first step in dermatoscopy, whereas the second step is to recognize lesions as malign or benign based on different dermatoscopic algorithms [8]. In clinical practice experienced dermatologists performing dermatoscopy mostly apply the first-step melanocytic algorithms (pattern analysis), i.e., they use the analysis of various dermatoscopic structures and colors. In general, clinical reliability of melanoma diagnostics by “naked eye” is assessed to be around 65%, whereas dermatoscopy significantly improves reliability to around 5-30% [9].

Nowadays there is a real need to advance early detection of scalp melanoma because of its significantly worse prognosis as compared with melanoma of other anatomic locations [10]. So far there have been very few descriptions of dermatoscopic structures of melanoma on the scalp and the first case was demonstrated and published by Zalaudek et al. in 2004 [11]. That case describes scalp melanoma with multi-component global structure, i.e., atypical pigment network, irregular streaks and regression structures. Dermatoscopic structures in the case had morphologically almost identical characteristics of melanoma located on trunk, as opposed to face melanoma, which shows completely different dermatoscopic structures: asymmetric follicular openings, annular-granular pattern, rhomboidal structures, homogeneous areas and slate-grey aggregated dots [12]. In the differential diagnosis of scalp melanoma blue nevus is on the first place (common or classic blue nevus), whereas a variant of cellular blue nevus is usually found in the area of gluteus [13]. The differential diagnosis may also include tumors classified as non-melanocytic, primarily pigmented basal cell skin cancer, acanthotic type of seborrheic keratosis, and pigmented type of actinic kratosis.

There is a dermatoscopic tracing of the so called clue to direct the dermatologist performing dermatoscopy to the right diagnosis, and to the recommendation for further choice of treatment or just further dermatoscopic follow-up [14]. In the scalp region metastases of melanoma of some other anatomic locations of skin may be found, including cutaneous metastases of other cancers such as breast cancer [15], which clinically imitate malign melanoma of the scalp. Melanoma is a common tumor in human pathology. Generally, incidence and mortality vary in the world depending on risk factors primarily. Scalp melanoma is classified as hidden melanoma, and due to delayed diagnostics it is considered to be an “invisible killer”. As it has a worse prognosis as compared with melanoma on other anatomic locations, the examination of the scalp should be a mandatory part of the clinical-dermatoscopic skin examination (TBSE-total body skin examination).

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 151
  • [From(publication date):
    June-2017 - Sep 27, 2017]
  • Breakdown by view type
  • HTML page views : 123
  • PDF downloads :28
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords