alexa Vitamin B12 Deficiency in Older Diabetic Patients: Is it Necessary to Create Guidelines for Early Diagnosis, Monitoring and Treatment of this Nutritional Problem?
ISSN: 2155-6156
Journal of Diabetes & Metabolism
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Vitamin B12 Deficiency in Older Diabetic Patients: Is it Necessary to Create Guidelines for Early Diagnosis, Monitoring and Treatment of this Nutritional Problem?

Dominique Masferrer1* and Hugo Sánchez2

1Department of Nutrition, Faculty of Medicine, University of Chile, Chile

2Public Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Chile

*Corresponding Author:
Dominique Masferrer
Researcher, Department of Nutrition, University of Chile
Avenida Independencia 1027, Santiago, Chile
Tel: 56229781460
E-mail: [email protected]

Received date: November 12, 2014; Accepted date: December 23, 2014; Published date: December 25, 2014

Citation: Masferrer D, Sánchez H (2015) Vitamin B12 Deficiency in Older Diabetic Patients: Is it Necessary to Create Guidelines for Early Diagnosis, Monitoring and Treatment of this Nutritional Problem? J Diabetes Metab 6:487. doi: 10.4172/2155-6156.1000487

Copyright: © 2015 Masferrer D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Diabetes & Metabolism

Abstract

.

According to reports from the World Health Organization, the aging population in both developed and in developing countries it has been possible due an improvement in access and coverage of health systems which has enabled a reduction in overall mortality rates and increased life expectancy of individuals [1]. However, this situation represents a challenge because it is necessary to maintain the achievements made in health and also generate environmental and sanitary conditions to ensure healthy aging and prevent pharmacological latrogenesis during the treatment of chronic diseases.

Considering that the nutrition in the elderly is a key element to achieving a good health, is essential to identify the requirements of critical nutrients during the aging. Among nutritional factors, vitamin B12 is essential for healthy aging. Vitamin B12 deficiency is associated with psychiatric and neurological diseases such as peripheral neuropathy and cognitive impairment [2,3] and hematological diseases (megaloblastic anaemia) [4]. Moreover, low serum vitamin B12 levels are associated with an increase of serum total homocysteine concentrations and increased cardiovascular risk [5,6].

Vitamin B12 deficiency is common in older adults and is considered a worldwide public health problem [7- 10]. International health agencies recommend that adults over the age of 50 get most of vitamin B12 from supplements or fortified foods [11]. However, these recommendations are not always considered by health professionals when they are prescribing dietary guidelines for older adults.

In this context, the situation of elderly diabetics it is worrying because apparently they would have an additional risk factor for the development of this nutritional problem. Several studies have identified that prolonged use of high doses of metformin represent a risk factor for vitamin B12 deficiency [12-17]. Considering that the use of this drug is recommended at the time of the diagnosis of disease (in addition of changes in lifestyles), the time of exposure to this risk factor would be quite extensive. It is estimated that after 10-12 years of use of this drug, clinical signs of vitamin B12 deficiency are evident [12], a period that represents an opportunity to be prevented the appearance of this nutritional problem.

According to what is stated in the literature review for Mazokopakis et al. [12] the relationship between metformin use and the associated risk to develop vitamin B12 deficiency is described in diabetic patients since 1969. Since then, observational and clinical studies have confirmed this association but the mechanisms of this association are still unclear. However, some authors note that this studies have presented methodological limitations, which have been related to the use of serum or plasma vitamin B12 levels as the sole indicator of vitamin B12 deficiency, despite that methylmalonic acid and holotranscobalamin measurements have changed the clinical practice of diagnosing B12 deficiency in recent years [12,18]. Other limitations of these studies have been the large variability in the dose and duration of metformin therapy [12].

Despite the disagreements on the relationship between metformin use and risk of vitamin B12 deficiency, Diabetes Mellitus type 2 is one of the conditions that produce more disease burden in the world [19] and the risk that older adults develop B12 deficiency is high [20-22], therefore is important to create guidelines that enhance the importance of monitoring serum levels of this vitamin and screening mechanisms to enable timely diagnosis of this nutritional problem in the elderly population and specifically those who are diabetic.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

  • International Conference on Internal Medicine May 21-22, 2018 Osaka, Japan
    May 21-22, 2018 Osaka, Japan
  • International conference on Fitness and Expo June 04-05, 2018 Baltimore, Maryland, USA
    June 4-5, 2018 Baltimore, USA
  • Annual Congress on Research and Innovations in Medicine July 02-03, 2018 Bangkok, Thailand
    July 02-03, 2018 Bangkok, Thailand
  • International Conference on Medical and Health Science August 24-25, 2018 Tokyo, JAPAN
    August 24-25, 2018 Tokyo, Japan

Article Usage

  • Total views: 12445
  • [From(publication date):
    January-2015 - Apr 24, 2018]
  • Breakdown by view type
  • HTML page views : 8611
  • PDF downloads : 3834
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version