Reach Us +1-947-333-4405
Yoga has Beneficial Effects on Patients with Chronic Diseases and Improves Immune Functions | OMICS International
ISSN: 2155-9627
Journal of Clinical Research & Bioethics

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Yoga has Beneficial Effects on Patients with Chronic Diseases and Improves Immune Functions

Nobuhiko Eda*

Waseda University, Faculty of Sport Sciences, Tokorozawa, Saitama, Japan

*Corresponding Author:
Nobuhiko Eda
Waseda University, Faculty of Sport Sciences
Tokorozawa, Saitama, Japan
Tel: +81 4 2947 6721
Fax: +81 4 2947 6721
Email: [email protected]

Received date: July 22, 2014; Accepted date: October 16, 2014; Published date: October 18, 2014

Citation: Eda N (2014) Yoga has Beneficial Effects on Patients with Chronic Diseases and Improves Immune Functions. J Clinic Res Bioeth 5:197. doi:10.4172/2155-9627.1000197

Copyright: © 2014 Eda N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Clinical Research & Bioethics


The practice of various styles of yoga has become popular in Western countries. Recently, chronic diseases, such as chronic obstructive pulmonary disease (COPD), cancer, cardiovascular diseases (CVD), obesity and diabetes mellitus, have emerged as serious problems worldwide, and it has become important for older adults to maintain or improve their immune functions. Yoga has been reported to have positive effects on distress and functional performance in patients with chronic diseases and improves several immunological indicators. In this paper, we review recent studies that have examined the effects of yoga on chronic diseases, especially COPD and cancer, and immune functions including those mediated by human β-defensin 2 (HBD-2), natural killer (NK) cells, and proinflammatory cytokines. We suggest that yoga has a potential use as a complementary and alternative therapy for chronic diseases, and we expect yoga to be useful for older adults who wish to maintain their health.


Yoga; Chronic obstructive pulmonary disease; Cancer; Defensin; Natural killer cells; Proinflammatory cytokines


The word “yoga” comes from Sanskrit “Yuj”, which means to yoke or to join together. Yoga is thought to have originated in India approximately 4,500 years ago and several styles of yoga continue to be practiced in the world today. Raja yoga mainly involves mediation, and the eight phases of this yoga practice have considerably influenced other yoga styles. Hatha yoga, which emphasizes the notion of life energy (prana), is a driving force for the mind and body; practitioners of Hatha yoga attempt to control the mind by using the flow of prana. Ashtanga and Iyengar yoga are subtypes of Hatha yoga. Practitioners of Ashtanga yoga try to achieve a deeper state of meditation by harmonizing breathing with movements, whereas the purpose of Iyengar yoga is to take control of the mind by using postural regulation. The detailed adjustment of postures is the most significant feature of this yoga style. Recently, the popularity of various types of yoga in Western countries has increased, including power yoga that combines Ashtanga Iyengar styles, Bikram yoga that is practiced under hot and humid conditions, and laughter yoga that combines laughter exercises with yogic breathing. Recent studies in which the relationship between yoga and chronic diseases and immune functions has been examined are reviewed in this paper.

Yoga and chronic diseases

The World Health Organization has reported that 64 million people have developed chronic obstructive pulmonary disease (COPD). Three million people died of COPD in 2004, and it is predicted to become the third leading cause of death worldwide by 2030 [1]. COPD is a lung ailment characterized by persistent blockage of airflow and symptoms such as breathlessness, abnormal sputum, and chronic cough. In a study of 29 elderly patients with COPD, participation in a 12-week Iyengar yoga training program reduced dyspnea-related distress (Baseline; 2.6 ± 2.8, 12-week; 1.6 ± 1.7, effect size (ES)=0.67, p=0.08) and improved the functional performance of patients (Baseline; 2.0 ± 0.5, 12-week; 2.2 ± 0.4, ES=0.79, p=0.04) compared to usual-care control group [2]. In another study of 25 patients with COPD, the anxiety score (pre-Iyengar yoga; 3.91 ± 1.03, post-Iyengar yoga; 4.50 ± 0.76) in the Hospital Anxiety and Depression Scale and the fatigue score (pre-Iyengar yoga; 6.63 ± 4.63, post-Iyengar yoga; 3.25 ± 1.98) in the Chronic Respiratory Questionnaire improved significantly. Moreover, the clinically important scores of these patients changed after they completed the 12-week Iyengar yoga program [3].

Cancer is a leading cause of death worldwide. According to a report released by the International Agency for Research on Cancer, the total number of cancer deaths was 8.2 million in 2012, with lung (1.59 million deaths), liver (745 thousand deaths), stomach (723 thousand deaths), colorectal (694 thousand deaths), and breast cancers (521 thousand deaths) causing the highest number deaths [4]. Chandwani et al. [5] investigated the effect of a 6-week yoga program on the quality of life (QOL) of 163 breast cancer patients. The physical component scale scores and physical functioning of the yoga group improved to a greater extent than those of the control group at 1 and 3 months after radiotherapy. In a study of mindfulness-based cancer recovery (MBCR), which involved mindfulness meditation and gentle yoga, stress symptoms and QOL showed greater improvements in the MBCR group than in the control group [6].

Cardiovascular diseases (CVD) are the most common cause of death in the world. According to an announcement by the World Health Organization (WHO), the number of deaths from CVD was about 17.3 million in 2008, representing 30% of all global deaths, and will increase to reach 23.3 million by 2030 [7-9]. The most important risk factors of CVD are obesity, diabetes mellitus. Sarvottam et al. [10] reported that a short-term yoga-based lifestyle intervention for 2 hours each day for 10 days decreased interleukin (IL)-6 and increased adiponectin in 51 overweight and obese men. High levels of IL-6 and low levels of adiponectin were associated with CVD risk. Therefore, a short-term yoga-based lifestyle intervention may be an important modality to reduce the risk for CVD as indicated by a decrease in IL-6 and an increase in adiponectin in overweight and obese men. In the study of 231 patients with type 2 diabetes mellitus, fasting blood glucose, serum total cholesterol, very LDL and malondialdehyde decreased and the activity of superoxide dismutase increased in the yoga groups after the 6-months Hatha yoga program [11]. Hunter et al. [12] investigated the effect of Bikram yoga on arterial stiffness and insulin resistance in 24 young and 18 older adults. As a result, total and low-density lipoprotein cholesterol levels, plasma insulin concentrations, and scores on the homeostatic model of the assessment of insulin resistance decreased in older adults, and carotid artery compliance increased and β-stiffness index decreased in young adults after the yoga program.

Taken together, these finding suggest that yoga has positive effects on patients with chronic diseases including COPD, breast cancer, obesity and diabetes mellitus. The practice of various styles of yoga has become popular recently, and yoga has been used as complementary and alternative therapy in Western countries.

Yoga and immune functions

Recently, yoga has been reported to improve various immunological parameters. Defensin antimicrobial peptides exert their effects by destroying the hydrophobic core of the lipid bilayers belonging to microbes. Human β-defensin 2 (HBD-2) is expressed in the epithelial cells of the oral cavity and respiratory tract. In a previous study, we showed that yogic stretching for 90 min increased salivary HBD-2 concentrations and HBD-2 expression rate in 15 older adults [13]. HBD-2 expression is known to be responsive to emotional stress. Therefore, we proposed that the relaxing effect of yogic stretching decreases stress, in turn increasing salivary HBD-2 expression.

Natural killer (NK) cells, a type of lymphocyte, play an important part in the innate immune system by eliminating damaged and cancer cells. The low cytotoxic activity of NK cells is associated with increased cancer risk. Kochupillai et al. [14] investigated the effects of yogic breathing on the numbers NK cells in cancer patients. In the yogic-breathing group, the numbers of NK cells increased significantly above baseline levels after 12 and 24 weeks of the practice and, after 24 weeks, significantly more NK cells were observed in the yogic-breathing group than in the control group. Witek-Janusek et al. [15] examined the relationship between Mindfulness-based Stress Reduction (MBSR), including yogic breathing practices, and immune function. Ninety-six women with breast cancer participated in a MBSR program for 8 weeks. NK cell activity and cytokine levels in the MBSR group returned to levels that comparable to those of the normal cancer-free group 4 weeks after completing MBSR therapy. In contrast, breast cancer patients in the non-MBSR group had low levels of NK cell activity and interferon (IFN)-γ production, and high levels of IL-4, IL-6, and IL-10 production. NK cells and T cells are the predominant cells types that secrete IFN-γ. IFN-γ exerts its proinflammatory function by activating endothelial cells, macrophages, and T cells, and by promoting the differentiation of T helper 1 (Th1) cells. Therefore, a decrease in serum IFN-γ levels indicates a decline in cellular immunity. Researchers have shown that serum IFN-γ levels decrease in patients under examination stress, however, IFN-γ levels in a group of patients who practiced yoga for 12 weeks were lower than in those belonging to the control group [16]. These findings suggest that the practice of yoga could inhibit the decline in cellular immunity that is associated with psychological stress.

Proinflammatory cytokines are known to modulate the pathologies of various chronic diseases and therapies for patients with chronic diseases are designed to reduce inflammation. The activations of transforming growth factor (TGF)-β, nuclear factor (NF)-κB, tumor necrosis factor (TNF)-α and IL-6 have been reported in the previous studies of COPD, chronic kidney disease, obesity and metabolic syndrome [17-19]. Yadav et al. [20] reported that yoga reduced stress and inflammation makers in 86 patients with chronic inflammatory diseases who participated in a short-term yoga-based lifestyle program for 10 days. The mean level of cortisol decreased and β-endorphins increased from baseline by day 10 in these patients. Mean reductions in IL-6 and TNF-α levels from baseline was also observed by day 10. In a study in which breast cancer patients participated in a 12-week Iyengar yoga program, the plasma levels of soluble TNF receptor type II, a marker of TNF activity, remained stable in the yoga group but increased in the control group [21]. In another study, 12-week Hatha yoga intervention improved the vitality of breast cancer survivors, while reducing the fatigue score estimated by the Multidimensional Fatigue Symptom Inventory – Short Form and the levels of IL-6, TNF-α, and IL-1β 3 months post-treatment. Increasing yoga practice decreases IL-6 and IL-1β production, but not TNF-α production [22]. Therefore, regular yoga exercise might reduce the levels of proinflammatory cytokines and could be an effective treatment for chronic diseases.


Here, we reviewed the effects of yoga practice on chronic diseases and immune functions. These results suggest that yoga might benefit patients with chronic diseases, decreasing their distress and improving their functional performance. The positive effects of yoga on several immunological indicators have been reported recently; thus, yoga could be effectively used by older adults to prevent infectious diseases. Yoga has potential utility as a complementary and alternative therapy for chronic diseases and can help older adults to maintain their health.

Key message

Yoga is a low- or moderate-intensity exercise that is practice for the purpose of relaxation, and it can be performed comfortably and easily by beginners and older adults. In this paper, we reviewed the beneficial effects of yoga on COPD, cancer, CVD, obesity, diabetes mellitus and immune functions; however, numerous studies have reported various positive effects of yoga on other diseases and mental stress. Therefore, yoga might be useful for the maintenance of health in older adults. A more detailed investigation of the effects of yoga on immune functions is warranted.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Article Usage

  • Total views: 14328
  • [From(publication date):
    November-2014 - Dec 17, 2018]
  • Breakdown by view type
  • HTML page views : 10420
  • PDF downloads : 3908

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry


[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7