alexa
Reach Us +44-1235-425476
Parasitic Helminths: A Useful Resource for Inflammatory and Autoimmune Disease Therapy | OMICS International
ISSN: 1948-593X
Journal of Bioanalysis & Biomedicine

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Parasitic Helminths: A Useful Resource for Inflammatory and Autoimmune Disease Therapy

Guofeng Cheng* and Jiaojiao Lin

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, China

*Corresponding Author:
Guofeng Cheng
Shanghai Veterinary Research Institute
Chinese Academy of Agricultural Sciences
Key Laboratory of Animal Parasitology
Ministry of Agriculture, China
Tel: 86-213-429-3659
Fax: 86-215-408-1818
E-mail:
[email protected]

Received Date: June 27, 2013; Accepted Date: August 17, 2013; Published Date: August 20, 2013

Citation: Cheng G, Lin J (2013) Parasitic Helminths: A Useful Resource for Inflammatory and Autoimmune Disease Therapy. J Bioanal Biomed 5: 075-076. doi: 10.4172/1948-593X.1000084

Copyright: © 2013 Cheng G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Bioanalysis & Biomedicine

Helminths are multicellular eukaryotic invertebrates with complex life cycles and development. Nematodes (roundworms) and platyhelminths (flatworms) are 2 groups of helminths that colonize the interior of humans. The nematodes include most of intestinal wormsand the filarial worms, whereas the platyhelminths include the flukes, such as the schistosomes, and the tapeworms [1]. Unlike other pathogens such as viruses, bacteria, or protozoa, helminths do not proliferate within their final hosts and the worm burdens in individual hosts depend on the number of initial parasites.

Over the last 40 years, there has been arapid increase in the incidence of some immune-mediated diseases such as inflammatory bowel diseases (IBD)(e.g., Crohn’s disease and ulcerative colitis), asthma, multiple sclerosis and autoimmune (type I) diabetes in industrialized, highly developed countries [2]. However, these diseases are not as common in lessdeveloped countries. The rapid increase in these diseases cannot be explained solely by genetic and/or environmental factors. Interestingly, epidemiology studies indicate that the geographical distribution of these diseases is negatively correlated with helminth-endemic areas [3,4].

Traditionally, parasitism refers to a “hateful” relationship: the parasite benefits at the expense of the health and nutrition of the host for its survival. Indeed, the host could benefit from parasites when colonizing helminths [5]. To some extent, immunological studies theoretically support this notion. Infection with helminth parasitesresults ina series of immune events that are dominated by T helper (Th) cell type 2 events [6,7]. Considering the reciprocity in immune regulation where, for example, Th2 cell-derived mediators inhibit the activity of Th1 cells, the hypothesis arises that individuals infected with helminth parasites could be less susceptible to the inflammatory diseases induced by the Th1 response [8]. Therefore, infection with helminths could be used to treat diseases driven by Th1 cells.

Studies on animal models [9-18] indicate that the severity of some immune mediated diseases such as Crohn’s disease, colitis, type 1 diabetes, asthma, and arthritis (Table 1) can be alleviated or even blocked upon infection with helminth parasites. These results are encouraging with respect to moving clinical trials toward human patients.

Helminths Effect of infection or injection Ref.
Nematode    
Ancylostoma caninum Inhibition of TNBS-induced colitis in mice by injecting A. caninum antigens [9]
Ascaris suum Chronic infection reduces eye disease in mice [10]
Trichinella spiralis Prevention of colitis in C57BL/6 mice [11]
Strongyloides stercoralis Suppression of pulmonary allergy in BALB/c mice [12]
Heligmosomoides polygyrus Inhibition of autoimmune type 1 diabetes in NOD mice [13]
Protection from colitis in C57BL/6 [27,28]
Platyhelminth    
Schistosoma mansoni     Inhibition of TNBS-induced colitis in mice by injecting S. mansoni antigens [9]
Inhibition of autoimmune type 1 diabetes in NOD mice [13]
Inhibition of type 1 diabetes in NOD mice by injecting S. mansoni antigens [14]
Prevention of DSS-induced colitis in BALB/c mice [15]
Suppression of collagen-induced arthritis in mice [16]
Schistosoma japonicum   Inhibition of asthma development in BALB/c mice by injecting the egg antigens   [17]
Protective effects for arthritis in DBA/1 mice [18]

Table 1: Examples of helminth parasites in animal models for inflammatory and autoimmune disease therapy.

Weinstock’s group carried out pioneering studies to investigate the effect of infection with helminth parasites on some inflammatory bowel diseases [19,20]. In early clinical trials, they showed that infection with helminths such as Trichuris suis can help prevent or even ameliorate Crohn’s disease without significant adverse effects [20]. Then, they commenced a randomized double blind placebo-controlled trial of T. suis in ulcerative colitis patients. This study indicated a significant improvement over that obtained with a placebo in patients receiving the agent [21,22]. In these studies, they used T. suis, a kind of pig whipworm, to consider the safety requirements for future medicine development. However, there are concerns that the deleterious effects due to parasite infection on host health may increase the risk of emergence of other infectious disease and of potential host-host transmission.

Consequently, the identification of bioactive molecules in helminth parasites that modulate the immune response of the host may provide an alternative strategy for utilizing parasitic helminths in the treatment of immune mediated diseases. Currently, several molecules such as Ascarissuum PAS1 [23], Dirofilariaimmitis-derived antigen (DiAg) [24] and filarial nematode ES-62 glycoprotein [25] have been shown to be involved in immunomodulation in animal models. An inhibitor of the apoptosis protein from Schistosoma japonicum (SjIAP) was also cloned and molecularly characterized by our group, andthe results indicated that SjIAP can inhibit caspase activity and caspase 3 expression in human 293T cells. Although the involvement of SjIAP in immunomodulation in the host remains to be determined, our preliminary study suggests that SjIAP could bea potential agent for treating liver injury, organ transplantation, and other diseases by inhibiting cellular apoptosis [26-28].

Parasitic helminths are a useful resource for inflammatory and autoimmune disease therapy. A deep understanding of the mechanisms of parasite infection and host immune response and of the molecular bases of these mechanisms is critical for developing therapeutic strategies for inflammatory and autoimmune diseases. The utilization of new “-omics” techniques such as secretomics, immunomics and metabolomics need to be accelerated to tap resources that can then be more beneficial for human beings.

Acknowledgements

The study was funded by the National Natural Science Foundation of China (Grant No. 30901068), Science and Technology Commission of Shanghai Municipality of China (Grant No.10410703400 and Grant No.10PJ1412300), and Shanghai Talent Developing Foundation of China (Grant No.2009032).

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 12440
  • [From(publication date):
    August-2013 - Dec 16, 2018]
  • Breakdown by view type
  • HTML page views : 8610
  • PDF downloads : 3830
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

streamtajm

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version