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ISSN: 2161-0401

Organic Chemistry: Current Research
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  • Research Article   
  • Organic Chem Curr Res 2014, Vol 3(1): 124
  • DOI: 10.4172/2161-0401.1000124

Palladium-Catalyzed Regioselective 2-Carbethoxyethylation of 1H– Indoles By C-H Activation: One-Step Synthesis of Ethyl 2-(1H-Indol-2-Yl) Acetates

Yi Zhang1,2, Jiang Wang2, Yong Nian1,2, Hongbin Sun1 and Hong Liu1,2*
1State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, P.R. China
2CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, , 555 Zuchongzhi Road, Shanghai 201203, P.R. China
*Corresponding Author : Hong Liu, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, P.R. China, Tel: 862150807042, Email: [email protected], [email protected]

Received Date: Dec 27, 2013 / Accepted Date: Jan 22, 2013 / Published Date: Jan 29, 2014

Abstract

An efficient and convenient method was developed for the one-step synthesis of various substituted ethyl 2-(1H-indol-2-yl) acetates via a palladium-catalyzed regioselective cascade C-H activation reaction. Importantly, this practical approach can be carried out with readily accessible starting materials and exhibits excellent functional group compatibility.

Keywords: Ethyl 2-(1H-Indol-2-yl) Acetates; C-H Activation; Palladium; Norbornene

Citation: Zhang Y, Wang J, Nian Y, Sun H, Liu H (2014) Palladium-Catalyzed Regioselective 2-Carbethoxyethylation of 1H–Indoles By C-H Activation: One-Step Synthesis of Ethyl 2-(1H-Indol-2-yl) Acetates. Organic Chem Curr Res 3: 124. Doi: 10.4172/2161-0401.1000124

Copyright: © 2014 Zhang Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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