Palladium-Catalyzed Regioselective 2-Carbethoxyethylation of 1HÃ¢Â€Â“ Indoles By C-H Activation: One-Step Synthesis of Ethyl 2-(1H-Indol-2-Yl) Acetates
Received Date: Dec 27, 2013 / Accepted Date: Jan 22, 2013 / Published Date: Jan 29, 2014
An efficient and convenient method was developed for the one-step synthesis of various substituted ethyl 2-(1H-indol-2-yl) acetates via a palladium-catalyzed regioselective cascade C-H activation reaction. Importantly, this practical approach can be carried out with readily accessible starting materials and exhibits excellent functional group compatibility.
Keywords: Ethyl 2-(1H-Indol-2-yl) Acetates; C-H Activation; Palladium; Norbornene
Citation: Zhang Y, Wang J, Nian Y, Sun H, Liu H (2014) Palladium-Catalyzed Regioselective 2-Carbethoxyethylation of 1H–Indoles By C-H Activation: One-Step Synthesis of Ethyl 2-(1H-Indol-2-yl) Acetates. Organic Chem Curr Res 3: 124. Doi: 10.4172/2161-0401.1000124
Copyright: © 2014 Zhang Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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