alexa А Targeted Drug Delivery System of Gd3+ for Neut
ISSN: 2155-983X

Journal of Nanomedicine & Biotherapeutic Discovery
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

А Targeted Drug Delivery System of Gd3+ for Neutron Capture Therapy against Cancer is Metalorganic Magnetic Nanoparticles

Olga V Kondrashina*

Department of Biophysics and Biotechnology, Department in co-operation with Pharmaceutical Chemistry and Pharmacognosy, Voronezh State University, Russia

*Corresponding Author:
Olga V Kondrashina
Department of Biophysics and Biotechnology
Department in co-operation with Pharmaceutical Chemistry and Pharmacognosym
Voronezh State University, Russia
E-mail: [email protected]

Received date: June 04, 2013; Accepted date: August 26, 2013; Published date: August 28, 2013

Citation: Kondrashina OV (2013) A Targeted Drug Delivery System of Gd3+ for Neutron Capture Therapy against Cancer is Metalorganic Magnetic Nanoparticles. J Nanomedine Biotherapeutic Discov 3:116. doi: 10.4172/2155-983X.1000116

Copyright: © 2013 Kondrashina OV. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A method for producing nanoparticles based Cholesteric Liquid Crystal Dispersion (CLCD) of complexed [DNA-Gd] with a high content of gadolinium ions (up to 400 mg/ml). Preparation can be stored in the laboratory for 200 days without changes in the physico-chemical properties. It is shown that the formation of nanoparticles of gadolinium ions bind to DNA molecules by interaction with both phosphate groups, and with the nitrogen bases, breaking the regular the secondary structure of DNA. It was found that the formation of nanoparticles significantly reduced solubility of double-stranded DNA and appears uncompensated positive charge on the surface of the complex, impeding its aggregation. The technique of nanoparticles based on a set CLCD [DNA-Gd], including the processing of the original particles CLCD double-stranded DNA with aqueous GdCl3. The magnetic properties of the nanoparticles, allowing maintain an active neutron diffusion exciting nuclide gadolinium directly on the hearth of a malignant tumor. Immobilization of nanoparticles performed by adsorption on macrophages defines active targeted delivery of gadolinium ions in lesions. The application of the local concentration of nanoparticles gadolinium is ~400 mg/ml, as a carrier for the neutron-exciting therapy of malignant neoplasms.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords