alexa 25-Hydroxyvitamin D Supplementation and BMI Change: A Meta-Analysis of Randomized Controlled Trials
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

25-Hydroxyvitamin D Supplementation and BMI Change: A Meta-Analysis of Randomized Controlled Trials

Mora N1*, Rieke K1, Plitcha J2, Segura AJ1, Leehey D3, DeShong K1, Kramer H1,3,4 and Durazo R1,4
1Public Health Program, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA
2Departments of Surgery, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA
3Medicine, Division of Nephrology and Hypertension, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA
4Department of Preventive Medicine and Epidemiology, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA
Corresponding Author : Nallely Mora
Public Health Program, Loyola Medical Center
2160 S. First Avenue, Maywood, IL 60153, USA
Tel: 708-327-9018
Fax: 708-327-9009
E-mail: [email protected]
Received June 06, 2013; Accepted July 07, 2013; Published July 09, 2013
Citation: Mora N, Rieke K, Plitcha J, Segura AJ, Leehey, D et al. (2013) 25-Hydroxyvitamin D Supplementation and BMI Change: A Meta-Analysis of Randomized Controlled Trials. J Obes Weight Loss Ther 3:181. doi:10.4172/2165-7904.1000181
Copyright: © 2013 Mora N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The impact of 25-hydroxyvitamin D (25[OH]D) supplementation on weight change remains controversial. The objective of this study was to summarize the effects of 25[OH]D supplementation (cholecalciferol or ergocalciferol) on BMI change through a meta-analysis of published clinical trials. We completed a systematic review of English articles, using MEDLINE (Ovid, Pubmed) from January 1, 1998 through January 1, 2013. The articles selected focused on 25[OH]D supplementation and body mass index (BMI) in randomized controlled trials (RCT’s). The association between 25[OH]D and mean BMI change was estimated utilizing a random effects model. A total of 30 studies were reviewed and 9 were included in the meta-analysis. Total participants included 1651 adults (82.6% women and mean age 47.9 years) and mean follow-up ranged between 6 to 196 weeks and mean daily 25[OH]D dose ranged from 200 IU to 1,110 IU. Five of the 9 studies included calcium supplementation in both groups. Average baseline BMI was 30.7 and 30.4 kg/m2 in the intervention and control groups, respectively. Five studies suggested a beneficial effect for 25[OH]D supplementation for BMI change whereas 3 studies showed no effect of 25[OH]D supplementation on BMI change, and one showed a non-perceptible change. Meta-analysis of BMI values at end of trial showed no statistically significant difference in BMI change by use of 25[OH]D supplementation. Based on existing published trials, oral 25[OH]D supplementation does not significantly impact BMI change.

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