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Hindi Research Article
25-Hydroxyvitamin D Supplementation and BMI Change: A Meta-Analysis of Randomized Controlled Trials
| Mora N1*, Rieke K1, Plitcha J2, Segura AJ1, Leehey D3, DeShong K1, Kramer H1,3,4 and Durazo R1,4 | |
| 1Public Health Program, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA | |
| 2Departments of Surgery, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA | |
| 3Medicine, Division of Nephrology and Hypertension, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA | |
| 4Department of Preventive Medicine and Epidemiology, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA | |
| Corresponding Author : | Nallely Mora Public Health Program, Loyola Medical Center 2160 S. First Avenue, Maywood, IL 60153, USA Tel: 708-327-9018 Fax: 708-327-9009 E-mail: moranallely@gmail.com |
| Received June 06, 2013; Accepted July 07, 2013; Published July 09, 2013 | |
| Citation: Mora N, Rieke K, Plitcha J, Segura AJ, Leehey, D et al. (2013) 25-Hydroxyvitamin D Supplementation and BMI Change: A Meta-Analysis of Randomized Controlled Trials. J Obes Weight Loss Ther 3:181. doi:10.4172/2165-7904.1000181 | |
| Copyright: © 2013 Mora N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
The impact of 25-hydroxyvitamin D (25[OH]D) supplementation on weight change remains controversial. The objective of this study was to summarize the effects of 25[OH]D supplementation (cholecalciferol or ergocalciferol) on BMI change through a meta-analysis of published clinical trials. We completed a systematic review of English articles, using MEDLINE (Ovid, Pubmed) from January 1, 1998 through January 1, 2013. The articles selected focused on 25[OH]D supplementation and body mass index (BMI) in randomized controlled trials (RCT’s). The association between 25[OH]D and mean BMI change was estimated utilizing a random effects model. A total of 30 studies were reviewed and 9 were included in the meta-analysis. Total participants included 1651 adults (82.6% women and mean age 47.9 years) and mean follow-up ranged between 6 to 196 weeks and mean daily 25[OH]D dose ranged from 200 IU to 1,110 IU. Five of the 9 studies included calcium supplementation in both groups. Average baseline BMI was 30.7 and 30.4 kg/m2 in the intervention and control groups, respectively. Five studies suggested a beneficial effect for 25[OH]D supplementation for BMI change whereas 3 studies showed no effect of 25[OH]D supplementation on BMI change, and one showed a non-perceptible change. Meta-analysis of BMI values at end of trial showed no statistically significant difference in BMI change by use of 25[OH]D supplementation. Based on existing published trials, oral 25[OH]D supplementation does not significantly impact BMI change.
