alexa 25-Methoxyl-Dammarane-3β, 12β, 20-Triol, A Ginseng Saponin Derivative and an Anticancer Agent: In Vitro and In Vivo Activities, Molecular Mechanism of Action, Pharmacokinetics and Structural Modification
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Commentary

25-Methoxyl-Dammarane-3β, 12β, 20-Triol, A Ginseng Saponin Derivative and an Anticancer Agent: In Vitro and In Vivo Activities, Molecular Mechanism of Action, Pharmacokinetics and Structural Modification

Shao Wu1, Meng Ding1, Xude Wang1, Wei Li1* and Yuqing Zhao1,2*

1School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China

2Key Laboratory of Structure-based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China

*Corresponding Authors:
Yuqing Zhao
Key Laboratory of Structure-based Drug Design
and Discovery of Ministry of Education
Shenyang Pharmaceutical University
Shenyang 110016, China
Tel: +862423986521
Fax: +862423986521
E-mail: [email protected]
Wei Li
School of Functional Food and Wine
Shenyang Pharmaceutical University
Shenyang 110016, China
Tel: +862423986521
Fax: +862423986521
E-mail: [email protected]

Received Date: March 03, 2017 Accepted Date: March 27, 2017 Published Date: March 30, 2017

Citation: Wu S, Ding M, Wang X, Li W, Zhao Y (2017) 25-Methoxyl-Dammarane- 3β, 12β, 20-Triol, A Ginseng Saponin Derivative and an Anticancer Agent: In Vitro and In Vivo Activities, Molecular Mechanism of Action, Pharmacokinetics and Structural Modification. Med Chem (Los Angeles) 7: 832-836. doi: 10.4172/2161-0444.1000437

Copyright: © 2017 Wu S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

25-Methoxyl-dammarane-3β,12β,20-triol (25-OCH3-PPD), a dammarane-type triterpene sapogenin isolated from Panax notoginseng, has shown strong antitumor effects in various human cancer cell lines, including prostate cancer, lung cancer, breast cancer, gastric cancer, colorectal cancer, pancreatic cancer, and hepatic fibrosis. This review focuses on the progress of research into 25-OCH3-PPD and its derivatives in cancer therapy, including in vitro and in vivo activities, structure-activity relationships, and the molecular mechanisms of action. In addition, we also summarized a method to evaluate the oral subchronic toxicity, improve oral bioavailability, and establish quality control standards for 25-OCH3-PPD. In this review, we have provided a detailed discussion of 25-OCH3-PPD and supplied a scientific reference for the research and development of 25-OCH3-PPD as a potential anticancer drug.

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