alexa 2-Aminoethyl Diphenylborinate (2-APB) Analogues: Part 3 - Regulators of Huntington Aggregation and Transglutaminase
ISSN: 2155-9538

Journal of Bioengineering & Biomedical Science
Open Access

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Research Article

2-Aminoethyl Diphenylborinate (2-APB) Analogues: Part 3 - Regulators of Huntington Aggregation and Transglutaminase

Shoichiro Ozaki*

The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

*Corresponding Author:
Shoichiro Ozaki
The Institute of Physical and Chemical Research
2-1 Hirosawa, Wako
Saitama 351-0198, Japan
Tel: 81-0467670991
E-mail: [email protected]

Received Date: June 5, 2014; Accepted Date: September 9, 2014; Published Date: September 16, 2014

Citation: Ozaki S (2014) 2-Aminoethyl Diphenylborinate (2-APB) Analogues: Part 3 - Regulators of Huntington Aggregation and Transglutaminase. J Bioengineer & Biomedical Sci 4: 131. doi: 10.4172/2155-9538.1000131

Copyright: © 2014 Ozaki S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Huntington aggregation inhibitory activities and transglutaminase inhibitory activities of 2APB analogues were measured. 2-APB analogues regulated the Huntington aggregation. This fact provided an example that 2-APB analogues can regulate cellular process. Diphenyl (aminoacidonate N,O) boranes, which are effective regulator of Ca2+ release and cellular process, were effective regulators of Huntington aggregation. It was also found that many of 2-APB analogues have moderate transglutaminase inhibition activities 2-Aminoethyl di(4-trifluorophenyl) borinate is a good transglutaminase regurator.

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