alexa 2-Aminoethyl Diphenylborinate (2-APB) Analogues: Part 4 - Poly-Boron Compounds: Regulators of Ca2+ Release and Consequent Cellular Processes
ISSN: 2155-9538

Journal of Bioengineering & Biomedical Science
Open Access

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Research Article

2-Aminoethyl Diphenylborinate (2-APB) Analogues: Part 4 - Poly-Boron Compounds: Regulators of Ca2+ Release and Consequent Cellular Processes

Shoichiro Ozaki*

The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

*Corresponding Author:
Shoichiro Ozaki
The Institute of Physical and Chemical Research
2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Tel: 81-0467670991
Fax: 81-0467670991
E-mail: ozaki-09[email protected]

Received Date: September 05, 2014; Accepted Date: October 07, 2014; Published Date: October 14, 2014

Citation: Ozaki S (2014) 2-Aminoethyl Diphenylborinate (2-APB) Analogues: Part 4 - Poly-Boron Compounds: Regulators of Ca2+ Release and Consequent Cellular Processes. J Bioengineer & Biomedical Sci 4: 134. doi: 10.4172/2155-9538.1000134

Copyright: © 2014 Ozaki S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Inhibitory activities of 74 poly-boron compounds for SOCE and IICR were measured. Activities of poly-boron compounds were compared with 2APB, mono-boron and bis-boron compounds. The IC50 of best poly-boron compound 1042 was 2 μM. This value was almost same as IC50 3 μM of 2-APB. Poly (aminoethoxyboryldiphenylether) 1042 is best candidate for regulation of Ca2+ release and consequent cellular processes in this paper.

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