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2D-QSAR Studies of Substituted Pyrazolone Derivatives as Anti-Inflammatory Agents | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

2D-QSAR Studies of Substituted Pyrazolone Derivatives as Anti-Inflammatory Agents

Rishikesh V. Antre*, Rajesh J. Oswal, Sandip S. Kshirsagar, Pranita P. Kore and Madhavi M. Mutha

Medicinal Chemistry Research Laboratory, JSPM`s Charak College of Pharmacy and Research, Pune, Maharashtra 412 207, India

*Corresponding Author:
Rishikesh V. Antre
Medicinal Chemistry Research Laboratory
JSPM`s Charak College of Pharmacy and Research
Pune, Maharashtra 412 207, India, Asia
Tel: +918888815377
Fax: +912027052590
E-mail: [email protected]

Received date: August 27, 2012; Accepted date: October 08, 2012; Published date: October 10, 2012

Citation: Antre RV, Oswal RJ, Kshirsagar SS, Kore PP, Mutha MM (2012) 2D-QSAR Studies of Substituted Pyrazolone Derivatives as Anti-Inflammatory Agents. Med chem 2:126-130. doi:10.4172/2161-0444.1000127

Copyright: © 2012 Antre RV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


A QSAR study was performed on a series of substituted pyrazolone derivatives. The compounds in the selected series were characterized by spatial, molecular and electrotopological descriptors using QSAR module of molecular design suite (V-Life MDS 4.0). In present research paper we reported 2D-QSAR studies of substituted pyrazolone derivatives. Correlations between inhibitory activities and calculated predictor variables were established through partial least square regression (stepwise forward) method.f


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