alexa 2-tert-butyl-1,4-benzoquinone Induces Apoptosis in Chronic Myeloid Leukemia Cells Resistant to Imatinib via Inducing Caspase-Dependent Bcr- Abl Downregulation
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

2-tert-butyl-1,4-benzoquinone Induces Apoptosis in Chronic Myeloid Leukemia Cells Resistant to Imatinib via Inducing Caspase-Dependent Bcr- Abl Downregulation

Xianping Shi1, Xiaoying Lan1, Xiaofen Li1, Xin Chen1, Bing Z. Carter2, Xuejun Wang1,3 and Jinbao Liu1*

1State Key Lab of Respiratory Disease, Protein Modification and Degradation Lab, Departments of Pathophysiology and Biochemistry, Guangzhou Medical University,Guangdong 510182, China

2Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA

3Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, South Dakota 57069, USA

*Corresponding Author:
Jinbao Liu
Protein modification and Degradation Lab
Department of Pathophysiology, Guangzhou Medical University
Guangzhou, Guangdong 510182, China
Tel: +8620-81340720
Fax: +8620-81340542
E-mail: [email protected]

Received date: November 11, 2014; Accepted date: December 10, 2014; Published date: December 12, 2014

Citation: Shi X, Lan X, Li X, Chen X, Carter BZ, et al (2014) 2-tert-butyl-1,4- benzoquinone Induces Apoptosis in Chronic Myeloid Leukemia Cells Resistant to Imatinib via Inducing Caspase-Dependent Bcr-Abl Downregulation. Med chem 4:786-790. doi: 10.4172/2161-0444.1000231

Copyright: © 2014 Shi X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Bcr-Abl-T315I mutation-induced imatinib (IM) resistance remains a major challenge for clinical management of chronic myelogenous leukemia (CML). Therefore it is imperative to search for novel agents to overcome IMresistance. 2-Tert-butyl-1,4-benzoquinone (TBQ) is an oxidation product of 2-tert-Butylhydroquinone (TBHQ) which has been developed as a food additive and proves to be a strong antioxidant. Previous studies showed that TBQ has cytotoxic effect on different types of neoplastic cells. Our recent study confirmed that TBQ induced apoptosis and cell proliferation inhibition in CML cells and inhibited the growth of IM-resistant primary monocytes from CML patients. Here we further report that TBQ-induced caspase activation is required for the downregulation of Bcr-Abl and apoptotic cell death in both IM-resistant and IM-sensitive CML cells. These findings suggest an alternative strategy to overcome IM resistance by enhancing Bcr-Abl downregulation with TBQ.

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