alexa 3’,6-Dimethoxy-3’’,4Ã
ISSN: 2167-7956

Journal of Biomolecular Research & Therapeutics
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

3’,6-Dimethoxy-3’’,4’’-Methylenedioxy-2,5-Epoxylignan-4’-ol Inhibited Glioma-Associated Oncogene

Yusnita Rifai1*, Midori Arai2 and Masami Ishibashi2

1Faculty of Pharmacy Hasanuddin University, Makassar 90245, Indonesia

2Graduate School of Pharmaceutical Sciences, Chiba University, Japan

*Corresponding Author:
Yusnita Rifai
Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia
Tel : +62-411-588556
Fax : +62-411-590663
E-mail: [email protected]

Received date: October 25, 2014; Accepted date: November 27, 2014; Published date: December 04, 2014

Citation: Rifai Y, Arai M, Ishibashi M (2014) 3',6-Dimethoxy-3'',4''-Methylenedioxy-2,5-Epoxylignan-4'-ol Inhibited Glioma-Associated Oncogene. J Biomol Res Ther 3:117. doi: 10.4172/2167-7956.1000117

Copyright: © Rifai Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Aberrant activation of Hedgehog (Hh) signaling pathway has been linked to the development of cancers. A naturally occurring Hedgehog inhibitor, 3’,6-dimethoxy-3’’,4’’-(methylenedioxy)-2,5-epoxylignan-4’-ol (DMEO), isolated from Piper nigrum, exhibited selective cytotoxicity against human pancreatic (PANC1) with no toxic effect on normal cells. This compound blocked the translocation of GLI transcription factors into the nucleus in PANC1. RNA interferences of the Smoothened (Smo) function in PANC1 treated with the compound downregulated the mRNA expression of Ptch.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords