alexa 3’,6-Dimethoxy-3’’,4Ã
ISSN: 2167-7956

Journal of Biomolecular Research & Therapeutics
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Research Article

3’,6-Dimethoxy-3’’,4’’-Methylenedioxy-2,5-Epoxylignan-4’-ol Inhibited Glioma-Associated Oncogene

Yusnita Rifai1*, Midori Arai2 and Masami Ishibashi2

1Faculty of Pharmacy Hasanuddin University, Makassar 90245, Indonesia

2Graduate School of Pharmaceutical Sciences, Chiba University, Japan

*Corresponding Author:
Yusnita Rifai
Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia
Tel : +62-411-588556
Fax : +62-411-590663
E-mail: [email protected]

Received date: October 25, 2014; Accepted date: November 27, 2014; Published date: December 04, 2014

Citation: Rifai Y, Arai M, Ishibashi M (2014) 3',6-Dimethoxy-3'',4''-Methylenedioxy-2,5-Epoxylignan-4'-ol Inhibited Glioma-Associated Oncogene. J Biomol Res Ther 3:117. doi: 10.4172/2167-7956.1000117

Copyright: © Rifai Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Aberrant activation of Hedgehog (Hh) signaling pathway has been linked to the development of cancers. A naturally occurring Hedgehog inhibitor, 3’,6-dimethoxy-3’’,4’’-(methylenedioxy)-2,5-epoxylignan-4’-ol (DMEO), isolated from Piper nigrum, exhibited selective cytotoxicity against human pancreatic (PANC1) with no toxic effect on normal cells. This compound blocked the translocation of GLI transcription factors into the nucleus in PANC1. RNA interferences of the Smoothened (Smo) function in PANC1 treated with the compound downregulated the mRNA expression of Ptch.

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