5 Hydroxy Cholecalciferol Levels in Infants with Hypocalcemic Seizures
- *Corresponding Author:
- Richa Malik
Resident, Department of Pediatrics
Vardhaman Mahavir Medical College & Safdarjang Hospital, New Delhi, India
E-mail: [email protected]
Received Date: February 27, 2014; Accepted Date: April 10, 2014; Published Date: April 14, 2014
Citation: Malik R, Mohapatra JN, Kabi BC, Halder R (2014) 5 Hydroxy Cholecalciferol Levels in Infants with Hypocalcemic Seizures. J Nutr Food Sci 4: 271. doi: 10.4172/2155-9600.1000271
Copyright: © 2014 Malik R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To determine the prevalence of vitamin D deficiency (25-hydroxycholecalciferol) in infants with hypocalcemic seizures and the relation of severity of vitamin D (25-hydroxy Cholecalciferol) deficiency with the occurrence of hypocalcemic seizures. Design: Cross sectional analytical study. Setting: pediatric emergency department of a tertiary care hospital. Methods: 60 consecutive term neonates and infants (upto 1 year) presenting with seizures with documented hypocalcemia (total serum calcium was <8 mg/dl, with normal serum albumin levels (≥4 mg/dl) were included as cases and 60 healthy term neonates and infants attending immunization clinic were taken as controls. A structured questionnaire was asked and blood samples taken for serum calcium, phosphorus, alkaline phosphatase, 25 hydroxycholecalciferol, albumin levels. Radiological assessment of rickets was also done in clinically suspected cases. Results: Majority of the cases had inadequate exposure to sunlight (73.3%) as compared to controls (41.7%). Vitamin D deficiency is seen in 88.3% cases and 68.3% controls (p=0.01). 31.7% of the cases were severely deficient in vitamin D. Thus vitamin D deficiency appears to be a major risk factor for hypocalcemic seizures. No significant relation between 25(OH)D and calcium in both cases and controls using spearman rank correlation. There was a significant inverse relation between 25(OH)D and S.ALP among controls and cases. Conclusion: High prevalence of vit D deficiency was noted in infants with hypocalcemic seizures however a high prevalence of vitamin D deficiency was also seen in healthy infants. Serum alkaline phosphatase can be taken as surrogate marker for vit D deficiency. Sunlight exposure < 30 minutes/week was likely to develop vitamin D Deficiency.