alexa A 6-weeks Treatment Program Improves HRV in Eating Diso
ISSN: 2168-9784

Journal of Medical Diagnostic Methods
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Research Article

A 6-weeks Treatment Program Improves HRV in Eating Disorder Patients

Herbert F. Jelinek1*, Mika P. Tarvainen2, David J. Cornforth3, Ian Spence4 and Janice Russell5

1School of Community Health, Charles Sturt University, Albury and Australian School of Advanced Medicine, Macquarie University, Sydney, Australia

2Department of Applied Physics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

3School of Design, Computing and Information Technology and Applied Informatics Group, University of Newcastle, Newcastle, Australia

4Discipline of Pharmacology, University of Sydney, Sydney, Australia

5Discipline of Psychiatry, University of Sydney, and North Side Clinic, Sydney, Australia

*Corresponding Author:
Herbert Jelinek
School of Community Health
Thurgoona Drive, Albury
NSW2640, Australia
Fax: +61260519219
E-mail: [email protected]

Received date: May 13, 2016; Accepted date: May 18, 2016; Published date: May 25, 2016

Citation: Jelinek HF, Tarvainen MP, Cornforth DJ, Spence I, Russell J (2016) A 6-weeks Treatment Program Improves HRV in Eating Disorder Patients. J Med Diagn Meth 5:211. doi:10.4172/2168-9784.1000211

Copyright: © 2016 Jelinek HF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Eating disorders such as anorexia nervosa present with a significant cardiovascular associated risk of sudden cardiac death. Bradycardia is a serious complication of eating disorders.

Methods: Eating Disorder (ED) patients were admitted to a 6-week treatment program and assessed for of heart rate variability (HRV) at entrance to the program and at discharge from hospital. Linear heart rate variability measures were determined using Kubios software from Lead 3 ECG recordings following a 5-minute rest period. Nonparametric statistics were applied and significance set at p < 0.05.

Results: No significant differences in HRV parameters were noted for the control group following the 6-week treatment program. For the ED group, mean RR interval length decreased significantly following treatment compared (median ± IQR; -64 ± 76; p = 0.002). Sympathovagal function was abnormal in the ED group on admission but improved following treatment, showing a decrease in RMSSD (median ± IQR; -9 ± 18; p = 0.048) and SD1 (median ± IQR; -6 ± 13; p = 0.048). Sample entropy, a, measure of heart rate complexity did not change significantly.

Conclusion: At admission to hospital the ED group was more parasympathetic during rest compared to controls, but they became more sympathetic after the intervention and approached the HRV measures of the controls.


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