alexa A Balanced Network: Transcriptional Regulation in Pluri
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

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Review Article

A Balanced Network: Transcriptional Regulation in Pluripotent Stem Cells

Lingyi Chen1* and Li-Feng Zhang2*

1The State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China

2School of Biological Sciences, Nanyang Technological University, Singapore 637551

Corresponding Authors:
Lingyi Chen
College of Life Sciences, Nankai University
94 Weijin Road, Tianjin, China
Tel: (86)-22-23505821
Fax: (86)-22-23505821
E-Mail: [email protected]
Li-Feng Zhang
School of Biological Sciences, Nanyang Technological University
60 Nanyang Drive, Singapore 637551
Tel: (65)-6316-7094
E-Mail: [email protected]

Received Date: April 12, 2012; Accepted Date: May 07, 2012; Published Date: May 09, 2012

Citation: Chen L, Zhang LF (2012) A Balanced Network: Transcriptional Regulation in Pluripotent Stem Cells. J Stem Cell Res Ther S10:004. doi:10.4172/2157-7633.S10-004

Copyright: © 2012 Chen L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Embryonic stem cells (ESCs) hold great promise for regenerative medicine. It has been an active research field to understand the molecular mechanisms underlying the pluripotency of ESCs. Self-renewal of ESCs relies on maintaining the unique transcriptional profile of ESCs, while differentiation of ESCs requires a flexible transcriptional profile so that it can be altered in different types of cells. Therefore, transcriptional regulation plays important roles in pluripotency. In this review, we summarize recent discoveries on how transcriptional regulation contributes to pluripotency maintenance in ESCs. We emphasize the functions of transcription factors in pluripotency maintenance, as well as in X chromosome inactivation and somatic cell reprogramming.


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