A Brief Review on Epigenetic Aspects involved in DepressionCatarine Lima Conti* and Adriana Madeira Alvares da Silva-Conforti
Department of Biology, Federal University of Espirito Santo, Alegre, ES, Brazil
- Corresponding Author:
- Catarine Lima Conti
Department of Biology, Federal University of Espirito Santo
Alegre, ES, Brazil
E-mail: [email protected]
Received Date: June 05, 2016; Accepted Date: July 08, 2016; Published Date: July 13, 2016
Citation: Conti CL, Alvares da Silva-Conforti AM (2016) A Brief Review on Epigenetic Aspects involved in Depression. Biol Med (Aligarh) 8:311. doi:10.4172/0974-8369.1000311
Copyright: © 2016 Conti CL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
It is known that external environmental or internal physiologic factors interact with an individual’s genetic constitution to determine risk for depression throughout life. This can be possible through epigenetic mechanisms that lead to changes in gene expression – with transgenerational abilities - that do not involve a change in the DNA sequence. Here we briefly summarize the link between depressive disorders and epigenetics, considering stressful events as important triggers for these modifications. The increasing knowledge in this issue is relevant for updating and expanding comprehension in the molecular basis of this mood disorder.