A Case of a Potential Drug Interaction between Phenobarbital and Darunavir-based Antiretroviral Therapy
- *Corresponding Author:
- Mark Naccarato
Department of Infectious Diseases and
HIV, St. Michael’s Hospital 30 Bond Street
4CCN, 4-177, Toronto, Ontario, Canada M5B 1W8
E-mail: [email protected]
Received date: November 17, 2015; Accepted date: February 01, 2016; Published date: February 06, 2016
Citation: Naccarato M, Yoong D, Fong I, Gough K (2016) A Case of a Potential Drug Interaction between Phenobarbital and Darunavir-based Antiretroviral Therapy. J AIDS Clin Res 7:541. doi:10.4172/2155-6113.1000541
Copyright: © 2016 Naccarato M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The cytochrome P450 isoform that is primarily involved in the metabolism of darunavir is CYP3A4. Drugs that modulate this enzyme would then be expected to alter the pharmacokinetics of darunavir.Phenobarbital, a traditional antiepileptic has been shown to have broad induction effects on CYP450 and glucuronidation systems and would be expected to affect any drug, including antiretrovirals that are handled by these systems. We report a case in which we believe decreased serum concentrations of darunavir may have been a result of a drug interaction with phenobarbital.