alexa A Case of Anaplastic Large Cell Lymphoma Presenting in Leukemic Phase
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

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Case Report

A Case of Anaplastic Large Cell Lymphoma Presenting in Leukemic Phase

Rahul Ravilla1*, Appalanaidu Sasapu1, Jeanette M Ramos2 and Konstantinos Arnaoutakis1

1Department of Hematology-Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA

2Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA

*Corresponding Author:
Rahul Ravilla
Department of Hematology-Oncology
University of Arkansas for Medical Sciences
Little Rock, 4301 W. Markham St., Slot
#634, Arkansas-72205, AR, USA
Tel: 501-313-9405
Fax: 501-686-6001
E-mail: [email protected]

Received date: September 22, 2015, Accepted date: October 24, 2015 Published date:October 31, 2015

Citation:Ravilla R, Sasapu A, Ramos JM, Arnaoutakis K (2015) A Case of Anaplastic Large Cell Lymphoma Presenting in Leukemic Phase. J Blood Disord Transfus 6:316. doi:10.4172/2155-9864.1000316

Copyright: © 2015 Ravilla R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Anaplastic lymphoma kinase (ALK) with positive Anaplastic Large Cell Lymphoma (ALCL) is has a distinct entity among the peripheral T-cell lymphomas. With a 5-year survival rate of 70%, it carries one of the best prognoses among peripheral T cell lymphomas. In rare instances, ALK positive ALCL presents in leukemic phase and it has a very poor prognosis with negligible number of cases reporting a survival rate of beyond one year. Following Case study as a research technique, the researchers tried to discuss about a patient affected by ALK positive ALCL in leukemic phase, associated with t (2;5)(p23;q35). The patient reported the clinic with a three week history of breathlessness, fever, diarrhoea, and axillary lymphadenopathy. His condition deteriorated in spite of rapid initiation of chemotherapy, and he succumbed to the high tumor burden. The study concludes that early diagnosis and institution of treatment is important in this regard. As this is a rare medical condition, with negligible alternative solutions, the present study underlines the need for further research in this area, emphasizing the need for newer therapies. It particularly stresses the need to examine the association of EBV and ALCL, with a specific reference to ALK-negative ALCL.

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