alexa A Case of Anti Glomerular Basement Membrane (GBM) Negative Goodpasture’s Disease | OMICS International | Abstract
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
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Case Report

A Case of Anti Glomerular Basement Membrane (GBM) Negative GoodpastureÂ’s Disease

Megan Borkum1, Gregory L Calligaro2 and Gregory Symons2*

1Division of General Medicine, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa

2Division of Respiratory Medicine, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa

*Corresponding Author:
Greg Symons
Division of Pulmonology, Department of Medicine
University of Cape Town, Groote Schuur 7937
South Africa
Tel: +27 21 404 4360
E-mail: [email protected]

Received date: August 22, 2014; Accepted date: October 31, 2014; Published date: November 04, 2014

Citation: Borkum M, Calligaro GL, Symons G (2014) A Case of Anti Glomerular Basement Membrane (GBM) Negative Goodpasture’s Disease .J Pulm Respir Med 4:213. doi:10.4172/2161-105X.1000213

Copyright: © 2014 Borkum M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Goodpasture's disease is a fulminant rapidly progressive disease characterized by autoantibodies to the alpha-3 chain of type IV collagen (Goodpasture's antigen). It can present as a glomerulonephritis alone, or as a pulmonaryrenal syndrome with alveolar haemorrhage. We report here a classical case of Goodpasture's disease presenting as a pulmonary-renal syndrome with serum anti-glomerular basement membrane (GBM) antibody negativity and positive perinuclear anti-neutrophil cytoplasm antibodies (p-ANCA).

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