A Case of Anti Glomerular Basement Membrane (GBM) Negative GoodpastureÂ’s DiseaseMegan Borkum1, Gregory L Calligaro2 and Gregory Symons2*
- *Corresponding Author:
- Greg Symons
Division of Pulmonology, Department of Medicine
University of Cape Town, Groote Schuur 7937
Tel: +27 21 404 4360
E-mail: [email protected]
Received date: August 22, 2014; Accepted date: October 31, 2014; Published date: November 04, 2014
Citation: Borkum M, Calligaro GL, Symons G (2014) A Case of Anti Glomerular Basement Membrane (GBM) Negative Goodpasture’s Disease .J Pulm Respir Med 4:213. doi:10.4172/2161-105X.1000213
Copyright: © 2014 Borkum M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Goodpasture's disease is a fulminant rapidly progressive disease characterized by autoantibodies to the alpha-3 chain of type IV collagen (Goodpasture's antigen). It can present as a glomerulonephritis alone, or as a pulmonaryrenal syndrome with alveolar haemorrhage. We report here a classical case of Goodpasture's disease presenting as a pulmonary-renal syndrome with serum anti-glomerular basement membrane (GBM) antibody negativity and positive perinuclear anti-neutrophil cytoplasm antibodies (p-ANCA).