A Case of Granulomatous Hepatitis and Pancytopenia Secondary to Bacillus Chalmette Guerin Immunotherapy (BCG)Federico Piñero*, Sebastián Marciano and Adrián Carlos Gadano
Liver Unit, Hospital Italiano, Buenos Aires, Argentina
- *Corresponding Author:
- Federico Piñero, MD
Liver Unit, Hospital Italiano, Buenos Aires
Argentina Av Juan Domingo Perón 4190/C1199ABD/Bs As/Argentina
Tel/Fax: (540230) 448-2236
E-mail: [email protected]
Received date: February 21, 2014; Accepted date: March 22, 2014; Published date: March 24, 2014
Citation: Piñero F, Marciano S, Gadano AC (2014) A Case of Granulomatous Hepatitis and Pancytopenia Secondary to Bacillus Chalmette Guerin Immunotherapy (BCG). Med chem 4:531-532. doi:10.4172/2161-0444.1000190
Copyright: © 2014 Piñero F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We describe the case of a 69-year-old female who developed pancytopenia and acute hepatitis as a complication of intravesical BCG instillations for the treatment of bladder urothelial carcinoma. Liver and bone marrow biopsies revealed multinucleated giant epithelioid cells and non-caseating granulomas. Treatment with antituberculosis drugs achieved complete resolution. This case illustrates an infrequent but severe complication of intravesical BCG instillations, whichcan be successfully treated without steroids.