A Case of Pfetin Negative Gastrointestinal Stromal Tumor (GIST), Metastasized to the Liver Five Years after Surgery: A Surgical ChallengeShunsuke Sakuraba1, Hajime Orita1*, Tomoaki Ito1, Tomoyuki Kushida1, Mutsumi Sakurada1, Hiroshi Maekawa1, Ryo Wada2 and Koichi Sato1
- *Corresponding Author:
- Hajime Orita
Department of Surgery
Juntendo Shizuoka Hospital
Tel: +81 55-948-3111
E-mail: [email protected]
Received date: January 12, 2016; Accepted date: January 28, 2016; Published date: January 30, 2016
Citation: Sakuraba S, Orita H, Ito T, Kushida T, Sakurada M, et al. (2016) A Case of Pfetin Negative Gastrointestinal Stromal Tumor (GIST), Metastasized to the Liver Five Years after Surgery: A Surgical Challenge. J Mol Biomarkers Diagn S8:014. doi:10.4172/2155-9929.S8-014
Copyright: © 2016 Sakuraba S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Background: Despite complete resection, GIST sometimes recurs and/or metastasizes. Accurate prognosis is needed and various risk stratification methods have been discussed. We have reported Pfetin as a risk factor for recurrence of GIST. In this study, we report a case of Pfetin-negative GIST of the stomach which was classified as low risk according to Fletcher-classification, but metastasized to the liver five years after surgery and was completely removed.
Case presentation: A 60-year-old-man with abdominal pain and hematemesis was diagnosed with GIST of the stomach. Though the risk of recurrence was low according to Fletcher-classification, Pfetin expression was negative. We performed long term frequent medical follow-up, and five years after partial resection of the stomach, the GIST metastasized to the liver and we resected it completely.
Conclusions: We experienced a case of GIST of the stomach which was assessed as low risk, but was Pfetinnegative. Pfetin-negative status alone indicated poor prognosis for this GIST. Pfetin-negative status may be an independent biomarker indicating poor prognosis for GIST. In Pfetin-negative cases, it is desirable that long term frequent medical checkup be performed even if other factors suggest that the GIST is low risk. Early detection of recurrence can lead to effective treatment.