alexa A Case of Pfetin Negative Gastrointestinal Stromal Tumor (GIST), Metastasized to the Liver Five Years after Surgery: A Surgical Challenge | OMICS International | Abstract

Journal of Molecular Biomarkers & Diagnosis
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

A Case of Pfetin Negative Gastrointestinal Stromal Tumor (GIST), Metastasized to the Liver Five Years after Surgery: A Surgical Challenge

Shunsuke Sakuraba1, Hajime Orita1*, Tomoaki Ito1, Tomoyuki Kushida1, Mutsumi Sakurada1, Hiroshi Maekawa1, Ryo Wada2 and Koichi Sato1

1Department of Surgery, Juntendo Shizuoka Hospital, Shizuoka, Japan

2Department of Pathology, Juntendo Shizuoka Hospital, Shizuoka, Japan

*Corresponding Author:
Hajime Orita
Department of Surgery
Juntendo Shizuoka Hospital
Shizuoka, Japan
Tel: +81 55-948-3111
E-mail: [email protected]

Received date: January 12, 2016; Accepted date: January 28, 2016; Published date: January 30, 2016

Citation: Sakuraba S, Orita H, Ito T, Kushida T, Sakurada M, et al. (2016) A Case of Pfetin Negative Gastrointestinal Stromal Tumor (GIST), Metastasized to the Liver Five Years after Surgery: A Surgical Challenge. J Mol Biomarkers Diagn S8:014. doi:10.4172/2155-9929.S8-014

Copyright: © 2016 Sakuraba S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited


Background: Despite complete resection, GIST sometimes recurs and/or metastasizes. Accurate prognosis is needed and various risk stratification methods have been discussed. We have reported Pfetin as a risk factor for recurrence of GIST. In this study, we report a case of Pfetin-negative GIST of the stomach which was classified as low risk according to Fletcher-classification, but metastasized to the liver five years after surgery and was completely removed.

Case presentation: A 60-year-old-man with abdominal pain and hematemesis was diagnosed with GIST of the stomach. Though the risk of recurrence was low according to Fletcher-classification, Pfetin expression was negative. We performed long term frequent medical follow-up, and five years after partial resection of the stomach, the GIST metastasized to the liver and we resected it completely.

Conclusions: We experienced a case of GIST of the stomach which was assessed as low risk, but was Pfetinnegative. Pfetin-negative status alone indicated poor prognosis for this GIST. Pfetin-negative status may be an independent biomarker indicating poor prognosis for GIST. In Pfetin-negative cases, it is desirable that long term frequent medical checkup be performed even if other factors suggest that the GIST is low risk. Early detection of recurrence can lead to effective treatment.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7