alexa A Case of Skin Necrosis after Extravasation of Intravenous Immunoglobulin
ISSN: 2161-0665

Pediatrics & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

A Case of Skin Necrosis after Extravasation of Intravenous Immunoglobulin

Young Hui Kim1* and Young Dae Kim2

1Department of Pediatrics, College of Medicine, Inje University, Seoul Paik Hospital, Seoul, Korea

2Pediatrics Division of Hematooncology, Department of Pediatrics, College of Medicine, Inje University, Seoul Paik Hospital, Seoul, Korea

*Corresponding Author:
Young Hui Kim
Department of Pediatrics
Inje University Seoul Paik Hospital
No. 85 2-Ga Jeo-dong
Jung-Gu, Seoul, 100-032, Korea
Tel: +82-2-2270-0057
Fax: +82-2-2270-0264
E-mail: [email protected]

Received Date: March 21, 2012; Accepted Date: September 28, 2012; Published Date: September 29, 2012

Citation: Kim YH, Kim YD (2012) A Case of Skin Necrosis after Extravasation of Intravenous Immunoglobulin. Pediat Therapeut 2:136. doi:10.4172/2161-0665.1000136

Copyright: © 2012 Kim YH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Extravasation of certain drugs can make an injury on the injection site. It occurs more often in the fragile skin of children and old people. Immunoglobulin treats immune-mediated diseases effectively, such as a primary deficiency of antibodies or autoimmune diseases. A 9 months old boy came to hospital complaining of a fever for 5 days. He had bilateral non-purulent conjunctival injection, erythema of the lips and rashes on the hands and feet. On the echocardiography, the left coronary artery was dilated. He was diagnosed with Kawasaki disease. We started an intravenous immunoglobulin injection. After 7 hours, edema and a change in skin color appeared at the intravenous injection site on his right hand. We removed the catheter and applied a cold pack. Under impression of phlebitis, we applied Mupirocin ointment and Prednicarbate ointment with a dressing, twice a day. Within an outpatient follow up period, a skin necrosis with pus emerged. Coagulase negative Staphylococcus was detected from the pus by microbial culture study. We referred the patient to the Department of Plastic Surgery, and operated a debridement of the skin necrosis and a full thickness skin graft. He was discharged from hospital without a certain problem. The lesion was cured and left a scar. There was no recurrence or exacerbation on the skin graft lesion within a follow up period of 6 months since the surgery. We report a rare case of skin necrosis after extravasation of intravenous immunoglobulin, which had not been reported in Korea before.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

envir[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version