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A Case Report of a Metastatic Adenocarcinoma of Lung with Dual Positivity for EGFR Mutation and ALK Fusion | OMICS International | Abstract
ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
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Case Report

A Case Report of a Metastatic Adenocarcinoma of Lung with Dual Positivity for EGFR Mutation and ALK Fusion

Mangesh P Kamath1, Kadabur Nagendrappa Lokesh1*, Govind Babu K1, Lakshmaiah KC1, Suresh Babu MC1and Usha Amirtham2

1Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore-29, India

2Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore-29, India

*Corresponding Author:
Kadabur Nagendrappa Lokesh
MBBS, MD, DM, Assistant Professor
Department of Medical Oncology
Kidwai Memorial Institute of Oncology
Bangalore-29, India
Tel: 091-8971609070
E-mail: [email protected]

Received date: August 31, 2015 Accepted date:October 28, 2015 Published date: November 05, 2015

Citation: Kamath MP, Lokesh KN, Babu GK, Lakshmaiah KC, Babu SKC, et al. (2015) A Case Report of a Metastatic Adenocarcinoma of Lung with Dual Positivity for EGFR Mutation and ALK Fusion. J Nucl Med Radiat Ther 6:262. doi:10.4172/2155-9619.1000262

Copyright: © 2015 Kamath MP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited

Abstract

Non-small cell lung cancer ranks among the most lethal cancers worldwide. The rate of epidermal growth factor receptor (EGFR) mutations and echinoderm microtubuleassociated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) gene fusion is the most common in younger age, non-smoking Asian adenocarcinoma lung cancer patients. EGFR mutations and ALK gene rearrangements are known to be mutually exclusive and as mutual causes of resistance to EGFR-tyrosine kinase inhibitors (TKIs) or ALK-TKIs. However, rarely such co-alterations do co-exist in some clinical cases. Here we report a 62 year old male, heavy smoker with cough, hemoptysis and fatigue. Histopathological examination of bronchoscopic guided biopsy showed adenocarcinoma histology. Staging evaluation, he was found to have stage IV disease on positron emission tomography-computed tomography scan. The biopsy blocks tested positive for both EGFR mutation and ALK fusion. Patient was initiated on tablet Gefitinib 250 mg once daily. To the best of our knowledge, there has been no report of dual EGFR mutation and ALK fusion positivity from India.

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