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A Case Report - Volatile Metabolomic Signature of Malignant Melanoma using Matching Skin as a Control | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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A Case Report - Volatile Metabolomic Signature of Malignant Melanoma using Matching Skin as a Control

Tatjana Abaffy1*, Mecker Möller2, Daniel D. Riemer3, Clara Milikowski4 and R. Anthony DeFazio5

1Molecular and Cellular Pharmacology, University of Miami, Miami, Fl, USA

2Dewitt Daughtry Department of Surgery, Division of Surgical Oncology, University of Miami, Miami, Fl, USA

3Marine and Atmospheric Chemistry, Rosenstiel School of Marine and Atmospheric Science, University of Miami, Miami, Fl, USA

4Department of Pathology, University of Miami, Miami, Fl, USA

5Department of Neurology, University of Miami, Miami, Fl, USA

*Corresponding Author:
Dr. Tatjana Abaffy, RMSB
Molecular and Cellular Pharmacology
Miller School of Medicine, University of Miami, Miami, Fl 33136
Tel: 305 243-1508
Fax: 305 243-455
E-mail: [email protected]

Received Date: April 18, 2011; Accepted Date: June 30, 2011; Published Date: July 12, 2011

Citation: Abaffy T, Möller M, Riemer DD, Milikowski C, DeFazio RA (2011) A Case Report - Volatile Metabolomic Signature of Malignant Melanoma using Matching Skin as a Control . J Cancer Sci Ther 3: 140-144. doi: 10.4172/1948-5956.1000076

Copyright: © 2011 Abaffy T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Melanoma is the most serious form of skin cancer. The quest for melanoma diagnostic biomarkers is paramount since early detection of melanoma and surgical excision represent the only effective treatment of this capricious disease. Our recent study tested the hypothesis that melanoma forms a unique volatile signature that is different than control, healthy tissue. Here, we are reporting a case study, the analysis of the volatile metabolic signature of a malignant melanoma using matched, non-neoplastic skin tissue from the same patient as a control. This is a significant improvement in the methodology, since it is well known that diet, skin type, genetic background, age, sex and environment all contribute to individual variation in the skin volatile signature. In the present study, we have identified 32 volatile compounds; 9 volatile compounds were increased in melanoma when compared to normal skin and 23 volatile compounds were detected only in melanoma and not in normal skin. Out of these 32 compounds, 10 have been reported previously by our group, thus confirming our results and adding additional confidence in our untargeted metabolomics approach for detection of melanoma biomarkers.

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