A Clearance Step will become Increasingly Crucial for Pretargeted Tumor Therapy when Tumor Accumulation is ImprovedGuozheng Liu*
Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, MA 01655, USA
- *Corresponding Author:
- Guozheng Liu
Ph D; Department of Radiology, University of Massachusetts Medical School
55 Lake Avenue North, Worcester, MA 01655, USA
Email: [email protected]
Received Date: January 23, 2016; Accepted Date: February 17, 2016; Published Date: February 22, 2016
Citation: Liu G (2016) A Clearance Step will become Increasingly Crucial for Pretargeted Tumor Therapy when Tumor Accumulation is Improved. J Cancer Clin Trials 1:106. doi: 10.4172/jcct.1000106
Copyright: © 2016 Liu G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This is a commentary on a paper we published in Cancer Biother Radiopharm 2010. This commentary addresses related concerns about adding a separate clearing agent in the pretargeted tumor therapy. Previous investigations of tumor pretargeting mostly focused on utilizing the characteristic rapid clearance of a small therapeutic effector to limit toxicity exposure to normal tissues, but at a price of reduced tumor accumulation. Nevertheless, at least in theory, this reduction of tumor accumulation is not inevitable. The effector structure should be able to be modulated for its highest tumor accumulation while keeping the normal tissue background of the free effector negligible. However, so far little effort has been made in this area. In connection with the reduction of the toxicity to normal tissues, inclusion of a clearing step is well known. This commentary is to indicate that, in the pretargeted tumor therapy, inclusion of a clearance step will be more crucial when tumor accumulation of the effector is improved. It is the prerequisite to redeem the benefit of improved tumor accumulation.