A Combined Treatment with Myo-Inositol and Monacolin K Improve the Androgen and Lipid Profiles of Insulin-Resistant PCOS Patients
|Vincenzo De Leo*, Maria Concetta Musacchio, Valentina Cappelli, Alessandra Di Sabatino, Claudia Tosti and Paola Piomboni|
|Molecular Medicine and Development Department, Obstetrics and Gynecology Clinic, University of Siena, Italy|
|Corresponding Author :||Prof. Vincenzo De Leo
Molecular Medicine and Development Department
University of Siena, Italy
E-mail: [email protected]
|Received July 30, 2013; Accepted September 21, 2013; Published September 23, 2013|
|Citation: Leo VD, Musacchio MC, Cappelli V, Sabatino AD, Cannoni A, et al. (2013) A Combined Treatment with Myo-Inositol and Monacolin K Improve the Androgen and Lipid Profiles of Insulin-Resistant PCOS Patients. J Metabolic Synd 2:127. doi:10.4172/2167-0943.1000127|
|Copyright: © 2013 Leo VD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Objective: We sought to assess and compare the effects of myo-inositol combined with monacolin k (Group A) versus inositol only (Group B) and metformin (Group C), on the clinical, hormonal, metabolic and lipid profiles of insulin-resistant PCOS patients.
Study design: 60 insulin resistant PCOS patients were randomly assigned into three groups. All groups were treated for 6 months with either myo-inositol and monacolin k, inositol only or metformin. Patients clinical, hormonal and metabolic profiles were compared between all groups, and within each group, prior and following the aforementioned treatment.
Results: All treatment arms improved patients’ clinical, hormonal and metabolic profiles, with a tendency toward better results in patients using the combination of myo-inositol and monacolin k.
Conclusion: The combined treatment with the natural products: monacolin K and myo-inositol represents a valid and well tolerated alternative to the common medical therapy, improving the PCOS related symptoms, with minimal side effects.