alexa A Combined Treatment with Myo-Inositol and Monacolin K Improve the Androgen and Lipid Profiles of Insulin-Resistant PCOS Patients
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Research Article

A Combined Treatment with Myo-Inositol and Monacolin K Improve the Androgen and Lipid Profiles of Insulin-Resistant PCOS Patients

Vincenzo De Leo*, Maria Concetta Musacchio, Valentina Cappelli, Alessandra Di Sabatino, Claudia Tosti and Paola Piomboni
Molecular Medicine and Development Department, Obstetrics and Gynecology Clinic, University of Siena, Italy
Corresponding Author : Prof. Vincenzo De Leo
Molecular Medicine and Development Department
University of Siena, Italy
Tel: +390577233465
Fax: +390577233454
E-mail: [email protected]
Received July 30, 2013; Accepted September 21, 2013; Published September 23, 2013
Citation: Leo VD, Musacchio MC, Cappelli V, Sabatino AD, Cannoni A, et al. (2013) A Combined Treatment with Myo-Inositol and Monacolin K Improve the Androgen and Lipid Profiles of Insulin-Resistant PCOS Patients. J Metabolic Synd 2:127. doi:10.4172/2167-0943.1000127
Copyright: © 2013 Leo VD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: We sought to assess and compare the effects of myo-inositol combined with monacolin k (Group A) versus inositol only (Group B) and metformin (Group C), on the clinical, hormonal, metabolic and lipid profiles of insulin-resistant PCOS patients.

Study design: 60 insulin resistant PCOS patients were randomly assigned into three groups. All groups were treated for 6 months with either myo-inositol and monacolin k, inositol only or metformin. Patients clinical, hormonal and metabolic profiles were compared between all groups, and within each group, prior and following the aforementioned treatment.

Results: All treatment arms improved patients’ clinical, hormonal and metabolic profiles, with a tendency toward better results in patients using the combination of myo-inositol and monacolin k.

Conclusion: The combined treatment with the natural products: monacolin K and myo-inositol represents a valid and well tolerated alternative to the common medical therapy, improving the PCOS related symptoms, with minimal side effects.


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