alexa A Commentary on the Use of Epstein-Barr Virus Specific
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
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A Commentary on the Use of Epstein-Barr Virus Specific Antibodies as Biological Markers in Multiple Sclerosis

Massimiliano Castellazzi1*, Maura Pugliatti1, Enrico Granieri1 and Enrico Fainardi2

1Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Via Aldo Moro 8, I-44124 Cona Ferrara, Italy

2Department of Experimental and Clinical Biomedical Sciences, University of Florence, Largo Brambilla 3, I-50134 Florence, Italy

Corresponding Author:
Massimiliano Castellazzi
Laboratory of Neurochemistry and Neuroimmunology
University of Ferrara, Via Aldo Moro
8 I-44124 Cona, Ferrara, Italy
Tel: +39-0532-236388
Fax: +39-0532-239649
E-mail: [email protected]

Received date: March 23, 2017; Accepted date: May 31, 2017; Published date: June 07, 2017

Citation: Castellazzi M, Pugliatti M, Granieri E, Fainardi E (2017) A Commentary on the Use of Epstein-Barr Virus Specific Antibodies as Biological Markers in Multiple Sclerosis. J Neurol Neurophysiol 8:428. doi:10.4172/2155-9562.1000428

Copyright: © 2017 Castellazzi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Multiple sclerosis (MS), a chronic demyelinating and neurodegenerative disease of the central nervous system (CNS), whose pathogenesis likely involves an interaction of environmental factors with a genetic predisposition. The hypothesis that Epstein-Barr virus (EBV), a ubiquitous human γ-herpesvirus may be a causal agent pivots on the evidence of EBV-specific antibodies high titers in MS patients as compared to controls, and on the observed direct association between such antibodies titers and disease activity. However, the literature on the possible etiological role of EBV is conflicting. This commentary aims to provide an overview on the use of EBV-specific antibodies as biomarkers in MS course.


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