alexa A Commentary on Treatment of Tricyclic Antidepressant Overdose | OMICS International| Abstract
ISSN: 2161-0495

Journal of Clinical Toxicology
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  • Commentary   
  • J Clin Toxicol 2019, Vol 9(2): 410

A Commentary on Treatment of Tricyclic Antidepressant Overdose

Rahul Sawhney1* and Peter A McCullough2
1Baylor University Medical Center, Dallas, TX, USA
2Baylor Heart and Vascular Institute, Dallas, TX, USA
*Corresponding Author : Rahul Sawhney, Baylor University Medical Center, Dallas, TX, USA, Tel: 214 820-3275, Fax: 281 845-7064, Email: [email protected]

Received Date: Mar 27, 2019 / Accepted Date: Apr 15, 2019 / Published Date: Apr 22, 2019


Tricyclic antidepressants are still widely used for depression and other indications today. These drugs have a narrow therapeutic window and can have significant toxicities, with their cardio toxicity being especially striking and potentially fatal. For these reasons, tricyclic antidepressants are a drug of choice for suicide attempts. A key component in the management of tricyclic antidepressant toxicity is the administration of intravenous sodium bicarbonate which has its own potential adverse effects. In this article, we provide a brief commentary on tricyclic antidepressant toxicity, potential treatments, and a brief case vignette to highlight possible morbidity from toxicity treatment itself.

Keywords: Amitriptyline; Tricyclic antidepressant; QTc prolongation; TCA overdose; QRS prolongation; EKG changes; Tricyclic antidepressant overdose

Citation: Sawhney R, McCullough PA (2019) A Commentary on Treatment of Tricyclic Antidepressant Overdose. J Clin Toxicol 9: 410.

Copyright: © 2019 Sawhney R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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