alexa A Comorbidity Study of Functional Gastrointestinal Disorders in Patients with Major Depressive Disorder
ISSN: 2167-1044

Journal of Depression and Anxiety
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Research Article

A Comorbidity Study of Functional Gastrointestinal Disorders in Patients with Major Depressive Disorder

Lili Shi1, Jinya Cao1, Nana Xiong1, Xiaohui Zhao1, Jing Jiang1, Liming Zhu2, Zhifeng Wang2, Xiaohong Sun2, Xiucai Fang2 and Jing Wei1*
1Department of Psychological Medicine, Peking Union Medical College Hospital, Beijing, China
2Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China
Corresponding Author : Professor Jing Wei, MD
Peking Union Medical College Hospital
Beijing, China, 100730
Tel: 86-10-69156061
Fax: 86-10-69156066
E-mail: [email protected]
Received: October 08, 2015 Accepted: December 15, 2015 Published: December 18, 2015
Citation: Shi L, Cao J, Xiong N, Zhao X, Jiang J, et al. (2016) A Comorbidity Study of Functional Gastrointestinal Disorders in Patients with Major Depressive Disorder. J Depress Anxiety 5:211. doi:10.4172/2167-1044.1000211
Copyright: © 2015 Shi L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: To investigate the comorbidity of functional gastrointestinal disorders (FGIDs) in current major depressive disorder (MDD) patients. Method: The prevalence of gastrointestinal symptoms and the comorbidity of FGIDs were studied in a set of consecutively enrolled current MDD patients in a general hospital psychiatric outpatient clinic from Mar, 17th, 2011 to Dec, 31st, 2011. A total of consenting 62 patients were included. MDD diagnosis was made by experienced psychiatrists according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. FGIDs diagnosis was based on Rome III diagnostic questionnaire and approved by gastroenterologists. Result: In this group, 58 (93.5%) reported gastrointestinal symptom, the most prevalent symptom is abdominal pain or bloating or discomfort (87.1%), followed by diarrhea or constipation (85.5%), decreased or increased appetite (83.9%), reduced or increased food intake (83.9%), burp or belching (77.4%), nausea or vomiting (46.8%). Forty-six of the total 62 patients (74.2%) met the criteria of one or more FGIDs. In these 46 patients, 30 (65.2%) patients have overlap syndrome (two or more FGIDs). Functional dyspepsia (FD) is the most prevalent (54.8%), then belching disorder (29.0%), functional heartburn (16.1%), unspecified functional bowel disorder (16.1%) and irritable bowel syndrome (12.9%). Conclusion: In current MDD patients, gastrointestinal symptoms are common and a large percentage of them can already be diagnosed as FGIDs comorbidity, which demands clinical attention and future research.

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