A Comparative Study of the Diclofenac with Different Preparation of Paracetamol for Post-Operative Analgesia Following Laparoscopic Cholecystectomy
Shashi Prakash, Sandeep Loha*, Rajesh Kumar Meena, Anil Kumar Paswan, Arvind Bhalekar and Yashpal Singh
Institute of Medical Sciences, BHU, Varanasi, UP, India
- *Corresponding Author:
- Sandeep Loha
Assistant Professor, Department of Anaesthesiology
Institute of Medical Sciences
BHU, Varanasi-221005, UP, India
E-mail: [email protected]
Received date: May 10, 2016; Accepted date: July 01, 2016; Published date: July 06, 2016
Citation: Prakash S, Loha S, Meena RK, Paswan AK, Bhalekar A, et al. (2016) A Comparative Study of the Diclofenac with Different Preparation of Paracetamol for Post-Operative Analgesia Following Laparoscopic Cholecystectomy. J Anesth Clin Res 7:638. doi:10.4172/2155-6148.1000638
Copyright: © 2016 Prakash S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Pain following surgery remains a very important concern which can lead to detrimental effect over cardiovascular system, central nervous system and respiratory system. To minimise pain several analgesics are used. In that matter multimodal analgesia with diclofenac and paracetamol combination is regularly used. The paracetamol available commercially is in different formulation; Paracetamol 100 mL solution for infusion (P), containing paracetamol, cysteine hydrochloride monohydrate, disodium phosphste dihydrate, hydrocholoric acid, mannitol and sodium hydroxide and Paracetamol and lignocaine 2 mL injection (PL), containing paracetamol, lignocaine hydrochloride and benzyl alcohol. We studied comparing both the formulations of these paracetamol in combination with diclofenac in laparascopic surgeries and we did not find any significant difference between these two in terms of demography, VAS, VRS and any other side effects. However the major difference in the cost between these two formulations makes a significant impact in the economic burden.