A Comparison of 25 ÃÂ¼g with 50 ÃÂ¼g Misoprostol for Cervical Ripening and Induction of LaborFrancis Olayemi Adebayo*, Olatunde Onafowokan and Nathaniel Adewole
Department of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Abuja-FCT, Nigeria
- *Corresponding Author:
- Francis Olayemi Adebayo
Department of Obstetrics and Gynecology
University of Abuja Teaching Hospital, Abuja-FCT, Nigeria
E-mail: [email protected]
Received date: June 27, 2017; Accepted date: July 12, 2017; Published date: July 25, 2017
Citation: Adebayo FO, Onafowokan O, Adewole N (2017) A Comparison of 25 μg with 50 μg Misoprostol for Cervical Ripening and Induction of Labor. J Women's Health Care 6:378. doi:10.4172/2167-0420.1000378
Copyright: © 2017 Adebayo FO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Misoprostol is increasingly being accepted as a standard agent for cervical ripening and induction of labor. The lowest effective dose is still not known. Materials and Methods: This was an open label clinical trial of one hundred and eighty four women with obstetrics or medical indications for induction of labor at University of Abuja Teaching Hospital, Abuja. Women were grouped to receive either 25 μg or 50 μg of intravaginal misoprostol. The main outcome measure was inductionvaginal delivery interval while the secondary outcome measures were requirements for oxytocin augmentation, mode of delivery, frequency of tachsystole/hyperstimulation, as well as feto-maternal outcomes. Data was analyzed using SPSS version 21.0. Chi-square test was used to compare categorical variables. Mann-Whitney test was used to analyze continuous variables of the two treatment groups. P-value of less than 0.05 was accepted as indicating statistical significance. Results: Mean induction delivery interval was 13.8 ± 5.9 and 14.0 ± 5.7 hours (P=0.842) with the 25 μg and 50 μg misoprostol respectively. The delivery rate within 24 hours of 66.3% (61/92,) in 25 μg group was lower than 67.4% (62/92) recorded in the 50 μg group but the difference was not statistically significant (P=0.156). The rates of caesarean section and operative vaginal delivery were similar in both groups. There were no significant difference in maternal side effects and neonatal outcomes among the women in the two groups. Conclusion: There were no statistically significant differences in the effectiveness and safety of either of the dose regimen over the other. The choice may therefore be guided by the physician’s experience, availability and/or departmental protocol.