A Comparison of Dexmedetomidine Versus Propofol on Hypotension During Colonoscopy Under Sedation
Anchalee Techanivate*, Tewarux Verawattaganon, Chuleeporn Saiyuenyong and Pornpatra Areeruk
MDepartment of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
- *Corresponding Author:
- Anchalee Techanivate
Department of Anesthesiology
Faculty of Medicine, Chulalongkorn University
E-mail: [email protected]
Received date: September 18, 2012; Accepted date: October 04, 2012; Published date: October 24, 2012
Citation: Techanivate A, Verawattaganon T, Saiyuenyong C, Areeruk P (2012) A Comparison of Dexmedetomidine versus Propofol on Hypotension during Colonoscopy under Sedation. J Anesth Clin Res 3:257. doi: 10.4172/2155-6148.1000257
Copyright: © 2012 Aggarwal A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Sedation for colonoscopy with propofol is often associated with decreasing in arterial blood pressure. Dexmedetomidine is a sedative drug with a highly selective alpha2 adrenoreceptor agonist. The direct action on blood vessels causes vasoconstriction and a possible increase of blood pressure. This study evaluates dexmedetomidine on suppression of decrease in blood pressure is compared with propofol for sedation during colonoscopy. Method: Seventy patients with ASA physical status I-III were randomly allocated into two groups to receive either dexmedetomidine or propofol for elective colonoscopy under sedation. Group P patient received 0.5 mcg/kg fentanyl over 5 min, followed by 1 mg/kg propofol. Group D patients was received 1 mcg/kg dexmedetomidine with 0.5 mcg/kg fentanyl over 5 min, followed by 20 mg propofol. The 20 mg propofol was titrated as required to achieve the target BIS and sedation score. Standard monitorization were provided in both groups before sedation (baseline), start of sedation (time=0) and every 5 min intervals.