alexa A Comparison of Impulse Oscillometry to Spirometry in t
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
Open Access

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Research Article

A Comparison of Impulse Oscillometry to Spirometry in the Evaluation of Exercise Induced Bronchoconstriction in Children with Asthma

Sebnem Ozdogan*, Danny Hsia, Isabelo Elisan, Cheryl Johnson, Karen Hardy

Department of Pediatric pulmonology, Sisli Hamidiye Etfal Research and Training Hospital, Istanbul, Turkey

*Corresponding Author:
Sebnem Ozdogan
Department of Pediatric pulmonology
Sisli Hamidiye Etfal Research and Training Hospital, Istanbul, Turkey
Tel: 0905325487729
E-mail: ozdogan65@hotmail.com

Received date: January 31, 2014; Accepted date: March 27, 2014; Published date: March 31, 2014

Citation: Ozdogan S, Hsia D, Elisan I, Johnson C, Hardy K (2014) A Comparison of Impulse Oscillometry to Spirometry in the Evaluation of Exercise Induced Bronchoconstriction in Children with Asthma. J Pulm Respir Med 4:180. doi:10.4172/2161-105X.1000180

Copyright: © 2014 Ozdogan S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Rationale: Impulse Oscillometry (IOS) is a noninvasive method to measure respiratory impedance. The use of IOS as an indirect measure of airflow obstruction compared to spirometry in the evaluation of Exercise-Induced Bronchoconstriction (EIB) has not been fully explored in children. In this study we aim to describe the IOS values, resistance at 5 Hz (R5rs) in subjects with EIB and without EIB. We also aim to compare whether IOS variables correlate with spirometry variables following exercise challenge test in asthmatic subjects.

Methods: We designed a cross sectional study involving subjects between 6-18 years old with a diagnosis of asthma who were referred to the pediatric pulmonary function lab for an exercise challenge test to rule out EIB. Spirometry and IOS were performed at baseline and at 5 minute intervals up to 20 minutes post exercise and again post bronchodilator.

Results: 43 subjects were enrolled. Of the 43 subjects, 15 had a 10% fall in FEV1 after exercise significant for EIB. Demographic characteristics (gender, age and ethnicity) were not different comparing subjects with EIB to those without EIB. There was a significant correlation between spirometry and IOS measurements at baseline, 1 minute, 5 minutes, 10 minutes, 15 minutes, 20 minutes and post bronchodilator after exercise (r= -0.75, -0.72, -0.72, -0.76, -0.75, -0.72 and -0.75 respectively, p<0.01) in asthmatic subjects without EIB. In asthmatic subjects with EIB, there was a significant correlation between spirometry and IOS measurements at baseline, 1 minute, and post bronchodilator after exercise (r=-0.55, -0.79 and -0.63 respectively p<0.05). There was weak correlation between spirometry and IOS measurements at 5 minutes, 10 minutes, 15 minutes and 20 minutes after exercise for asthmatic subjects with EIB.

Conclusion: A significant correlation was found between spirometry and IOS measurements of change in airway function in asthmatic patients both with EIB and without EIB.

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