alexa A Comparison of the Effects of Amlodipine and Hydrochlorothiazide Monotherapy on Lipid Metabolism in Hypertensive Nigerians with Type 2 Diabetes Mellitus | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

A Comparison of the Effects of Amlodipine and Hydrochlorothiazide Monotherapy on Lipid Metabolism in Hypertensive Nigerians with Type 2 Diabetes Mellitus

Godfrey BS Iyalomhe1*, Eric KI Omogbai2, Ambrose O Isah3, Osigbemhe OB Iyalomhe4, Folorunso L Dada5 and Sarah I Iyalomhe6

1Department of Pharmacology and Therapeutics, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria

2Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

3Department of Internal Medicine, College of Medical Sciences, University of Benin, Benin City, Nigeria

4Department of Physiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA

5Department of Medical Laboratory Science, Irrua Specialist Teaching Hospital (ISTH), Irrua, Nigeria

6Department of Public Health and Primary Health Care, Central Hospital, Auchi, Nigeria

*Corresponding Author:
Godfrey BS Iyalomhe
Department of Pharmacology and Therapeutics
College of Medicine, Ambrose Alli University, Ekpoma, Nigeria,
Tel: +234-8053973990, +234-8067500780
E-mail: [email protected]

Received date: October 23, 2012; Accepted date: November 22, 2012; Published date: November 27, 2012

Citation: Iyalomhe GBS, Omogbai EKI, Isah AO, Iyalomhe OOB, Dada FL, et al. (2012) A Comparison of the Effects of Amlodipine and Hydrochlorothiazide Monotherapy on Lipid Metabolism in Hypertensive Nigerians with Type 2 Diabetes Mellitus. J Diabetes Metab 3:229. doi: 10.4172/2155-6156.1000229

Copyright: © 2012 Iyalomhe GBS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Although the association between antihypertensive therapy and lipid profiles is well established, there are very limited reports regarding the same in hypertensive Nigerians with type 2 diabetes mellitus. The aim of this study is to evaluate the extent to which treatment with amlodipine or hydrochlorothiazide would affect lipid panels.

Materials and methods: Forty newly diagnosed hypertensive subjects with controlled type 2 diabetes mellitus aged 43-68 years were randomized to amlodipine and hydrochlorothiazide treatment groups. Each group comprised 20 patients (20 males and 20 females) and they were treated, respectively, with amlodipine 10 mg and hydrochlorothiazide 25 mg, all given once daily for 48 weeks. Body mass index, blood pressure and lipid parameters were evaluated at baseline (week 0) before treatment as well as at the end of 1, 3, 6, 12, 24, 36 and 48 weeks.

Results: The 2 medications significantly reduced blood pressure values, though the blood pressure-lowering effect of amlodipine was significantly greater compared with that of hydrochlorothiazide (P<0.01). Total cholesterol and triglyceride mean values were not significantly affected by drug treatment. Whereas amlodipine significantly increased high density lipoprotein cholesterol (P<0.0001) and significantly decreased low density lipoprotein cholesterol in males (P<0.001), hydrochlorothiazide did not cause any significant change in the variables.

Discussion: We observed that although both drugs significantly decreased blood pressure, hydrochlorothiazide may adversely affect serum lipid panel as compared with amlodipine that exerts a beneficial effect on it. Clinicians need to consider this in the choice of drug treatment.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7