alexa A Comprehensive Analysis of Markers for Neuroendocrine
ISSN: 2157-7099

Journal of Cytology & Histology
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Research Article

A Comprehensive Analysis of Markers for Neuroendocrine Tumors of the Lungs Demonstrates Estrogen Receptor Beta to be a Prognostic Markers in SCLC Male Patients

Curioni-Fontecedro A1*, Soldini D2, Seifert B3, Eichmueller T1, Korol D4, Moch H2, Weder W5 and Stahel RA1

1Clinic of Oncology, University Hospital Zurich, Zurich, Switzerland

2 Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

3Division of Biostatistics, Institute for Social and Preventive Medicine, University of Zurich, Zurich, Switzerland

4Cancer Registry, Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

5Division of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland

*Corresponding Author:
Curioni-Fontecedro Alessandra
Department of Oncology
University Hospital Zurich
Raemistrasse 100, 8091 Zurich, Switzerland
Tel: +41442558902
Fax: +41442554548
E-mail: [email protected]

Received Date: June 17, 2014; Accepted Date: July 26, 2014; Published Date: July 28, 2014

Citation: Curioni-Fontecedro A, Soldini D, Seifert B, Eichmueller T, Korol D, et al. (2014) A Comprehensive Analysis of Markers for Neuroendocrine Tumors of the Lungs Demonstrates Estrogen Receptor Beta to be a Prognostic Markers in SCLC Male Patients. J Cytol Histol 5:268. doi: 10.4172/2157-7099.1000268

Copyright: © 2014 Alessandra CF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Knowledge about the biology and prognostic markers of neuroendocrine tumours (NET) of the lungs is scarce. As sex steroids contribute to cell proliferation in various human tissues, we aimed at characterising the expression of steroid receptors in a broad cohort of probes from NET of the lungs and evaluated their possible prognostic impact. A total of 192 tumour specimens of NET of the lungs were collected, with 58 surgical specimens of typical carcinoids, 42 of atypical carcinoids, 32 of large cell neuroendocrine carcinomas and 60 of small cell lung cancer (SCLC). Analysis by immunohistochemistry for the following antigens was performed: estrogen receptor β (ERβ), ERα, PR (progesterone receptor), AR (androgen receptor), Thyroid transcription factor 1 (TTF1), synaptophysin and for chromograninA. ERβ was found to be expressed in more than 60% of tumor probes. Survival data were available from 126 patients. In SCLC patients a subgroup analysis showed a survival benefit in the group of male patients whose tumours expressed ERβ (p=0.008) and all SCLC patients whose tumours expressed both ERβ and chromograninA (p=0.02). Here we could demonstrate that ERβ expression is frequent through all NET of the lungs. Moreover, our results suggest that ERβ represents a favourable prognostic factor for SCLC male patients and all SCLC patients whose tumors co-expressed chromogranin A.

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