Neurological Disorders

A Current Understanding of Alzheimers Disease and the Prospects of Phytopharmacological Intervention as a Management Strategy

Abstract

Juma KK \r\n

Alzheimer’s disease is a mental disorder that accounts for 60-70% of dementia. Its specific causes have not been determined to date. It is understood as neurodegenerative diseases which progressively gets worse over time. It is characterized by short term memory loss, language disorientation, mood disorders, lack of motivation and self-care, and as well as behavioral challenges. Management’s strategies of AD are limited and are not effective. Common therapeutic mechanisms target the inhibition of acetyl cholinesterase and N-methyl D aspartate (NMDA). Post mortem evaluation and Magnetic resonance imaging techniques have demonstrated similarities between Multiple Sclerosis and Alzheimer’s disease in pathogenesis of the disease through neurodegeneration and inflammation. Similarly, findings using Echo-Color Doppler technique and MRI along other techniques have demonstrated a strong association of development of Chronic CerebroSpinal Venous Insufficiency (CCSVI) with MS resulting from vascular damage of jugular veins leading to changes in the hemodynamics in the brain.

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