alexa A Cyclooxygenase 2 Gene Polymorphism is a Risk Factor f
ISSN: 2329-6895

Journal of Neurological Disorders
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Short Communication

A Cyclooxygenase 2 Gene Polymorphism is a Risk Factor for the Complication of Medication Overuse Headaches in Patients with Migraines

Ishii M1*, Katoh H2, Kurihara T1, Saguchi KI3, Miyasaka Y4, Shimizu S1,5 and Kawamura M2
1Department of Pharmacology, Toxicology and Therapeutics, Division of Physiology and Pathology, Showa University School of Pharmacy, Tokyo 142-8555, Japan
2Department of Neurology, Showa University School of Medicine, Tokyo 142-8666, Japan
3Department of Pharmacy Education, Showa University School of Pharmacy, Tokyo 142-8555, Japan
4Department of Hospital Pharmaceutics, Showa University School of Pharmacy, Tokyo 142-8555, Japan
5Laboratory of Pharmacology, Department of Clinical Pharmacy, Yokohama College of Pharmacy, Yokohama 245-0066, Japan
Corresponding Author : Masakazu Ishii
Department of Pharmacology
Toxicology and Therapeutics
Division of Physiology and Pathology
Showa University School of Pharmacy
Tokyo 142-8555, Japan
Tel: 81-3-3784-8041
Fax: 81-3-3786-0481
E-mail: [email protected]
Received December 03, 2014; Accepted January 30, 2015; Published February 01, 2015
Citation: Ishii M, Katoh H, Kurihara T, Saguchi KI, Miyasaka Y, et al. (2015) A Cyclooxygenase 2 Gene Polymorphism is a Risk Factor for the Complication of Medication Overuse Headaches in Patients with Migraines. J Neurol Disord 3:206. doi: 10.4172/2329-6895.1000206
Copyright: © 2015 Ishii M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

We determined whether cyclooxygenase-2 (COX-2) gene polymorphisms were involved in the aggravation of migraines due to the overuse of medication. Polymorphisms in the COX-2 (rs20417, rs689466) gene were examined. Forty-seven patients with migraine (6 males and 41 females; 5 with migraines with aura (MA), 36 with migraines without aura (MO), 6 with MA + MO; 1 with MA and 21 with MO; 36.4 ± 10.3 years) and 22 patients with medication overuse headache (MOH) (1 male and 21 females; 39.6 ± 9.9 years) who had migraines participated in this study. The genotypes of each polymorphism were analyzed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods. No significant differences were observed in the genotypic distributions of rs20417 (C/C + G/C vs. G/G, p=0.220) between migraine patients and MOH patients. The frequencies of the rs689466 G/G genotype were significantly higher in patients with MOH than in patients with migraines (G/G vs. A/A+A/G, p=0.008). Furthermore, the frequencies of the rs689466 G/G genotype were significantly higher in patients with MOH who had migraines without aura (MO) than in patients with MO (G/G vs. A/A+A/G, p=0.001). The results of this study showed that the COX-2 polymorphism (rs689466) was independently related with the complication of MOH in patients with MO.

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