A First Clinical Case Report of West-Nile Viral Meningoencephalitis Complicated with Acute Pancreatitis in North America
- *Corresponding Author:
- Alain Babi
Division of Neurocritical Care
Department of Neurology, Duke University
Hospital, DUMC, Durham, USA
Tel: +1 802-847-0000
Email: [email protected]
Received Date: December 2, 2015 Accepted Date: February 19, 2016 Published Date: February 27, 2016
Citation: Babi MA, Waheed W, Wardi S (2016) A First Clinical Case Report of West-Nile Viral Meningoencephalitis Complicated with Acute Pancreatitis in North America. J Meningitis 1:104. doi: 10.4172/2572-2050.1000104
Copyright: © 2016 M-Alain Babi, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Most affected humans with west-nile virus (WNV), a mosquito-borne virus of the flaviviridae family, remain asymptomatic, while a minority may develop neurological manifestation such as meningitis, encephalitis or a flaccid paralysis. Gastro-intestinal symptoms such as anorexia and abdominal pain are less common, whereas full blown symptomatic acute pancreatitis has only been described twice in the literature. These cases occurred in the Netherlands and in Israel where WNV is fairly endemic. We report the first clinical case in North America of a previously healthy 52 year old man who developed full blown WNV meningo-encephalitis with concurrent acute pancreatitis. Acute WN viral meningo-encephalitis was confirmed by a lumbar puncture, while other causes of meningitis/encephalitis were excluded. Acute WNV pancreatitis was diagnosed clinically as well as by abnormal serological markers including elevated amylase and lipase levels. The patient was treated conservatively, and his symptoms gradually improved until full recovery, requiring a total of three weeks from onset. WNV and its complications are reviewed, in addition to a description of prior cases of pancreatitis associated with WNV infection.