A Frailty-Model-Based Method for Estimating Age-Dependent Penetrance from Family DataYun-Hee Choi*
Department of Epidemiology and Biostatistics, Western University, London, ON, Canada
- *Corresponding Author:
- Yun-Hee Choi
Department of Epidemiology and Biostatistics
Western University, London, ON, Canada
Tel: 519-661-2111 (86256)
E-mail: [email protected]
Received date: September 08, 2011; Accepted date: February 11, 2012; Published date: February 15, 2012
Citation: Choi YH (2012) A Frailty-Model-Based Method for Estimating Age-Dependent Penetrance from Family Data. J Biomet Biostat S1:006. doi:10.4172/2155-6180.S1-006
Copyright: © 2012 Choi YH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Accurate estimates of disease risk (penetrance) associated with inherited gene mutations are critical for the clinical management of individuals at risk, but this estimation raises many statistical challenges especially when performed in a family-based design. In this paper, we propose a general frailty model-based approach to accommodate this design, where the frailty random effect accounts for shared risk among family members not due to the observed risk factors. It is of major interest when the goal is to discover other genetic variations besides the major gene and to get accurate estimates of penetrance (i.e. unbiased by unknown confounding factors). This approach is further extended to accommodate missing genotypes in family members and the non-random ascertainment of the families. Simulation results show that the proposed method performs well in realistic settings. Finally, a family-based breast cancer study of the BRCA1 and BRCA2 genes is used to illustrate the method.