alexa A Gene Expression Profile of Peripheral Blood in Colorectal Cancer
ISSN: 1948-5948

Journal of Microbial & Biochemical Technology
Open Access

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Research Article

A Gene Expression Profile of Peripheral Blood in Colorectal Cancer

Chi-Shuan Huang1, Harn-Jing Terng2, Yu-Chin Chou3, Sui-Lung Su3, Yu-Tien Chang3,4, Chin-Yu Chen2, Woan-Jen Lee2, Chung-Tay Yao5, Hsiu-Ling Chou6, Chia-Yi Lee3,4, Chien-An Sun7, Ching-Huang Lai3, Lu Pai3,8, Chi-Wen Chang9*, Kang-Hwa Chen9, Thomas Wetter10, Yun-Wen Shih3,4 and Chi-Ming Chu3,4*

1Division of Colorectal Surgery, Cheng Hsin Rehabilitation Medical Center, Taiwan

2Advpharma, Inc., Taipei, Taiwan

3School of Public Health, National Defense Medical Center, Taiwan

4Division of Biomedical Statistics and informatics, School of Public Health, National Defense Medical Center, Taiwan

5Department of Surgery, Cathay General Hospital, Taipei, Taiwan.

6Department of Nursing, Far Eastern Memorial Hospital & Oriental Institute of Technology, New Taipei, Taiwan.

7Department of Public Health, Fu Jen Catholic University, Taiwan

8Taipei Medical University, Taiwan

9Department of Nursing, College of Medicine, Chang Gung University, Taiwan

10Institute of Medical Biometry and Informatics, Heidelberg University, Germany and Department of Biomedical Informatics and Medical Education, University of Washington Seattle, USA

*Corresponding Author:
Prof. Dr. Chi-Ming Chu
Division of Bioinformatics and Statistics
Department of Epidemiology, School of Public Health
National Defense Medical Center, Taiwan
Tel: 886-2-87923100 X18438
Fax: 886-2-87923147
E-mail: [email protected]

Dr. Chi-Wen Chang
Department of Nursing, College of Medicine
Chang Gung University, Taiwan
E-mail: [email protected]

Received date: January 15, 2014; Accepted date: February 12, 2014; Published date: February 19, 2014

Citation: Huang CS, Terng HJ, Chang CW, Chou YC, Chang YT, et al. (2014) A Gene Expression Profile of Peripheral Blood in Colorectal Cancer. J Microb Biochem Technol 6:102-109. doi: 10.4172/1948-5948.1000129

Copyright: © 2014 Huang CS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Optimal molecular markers for detecting colorectal cancer (CRC) in a blood-based assay were evaluated. Microarray technology has shown a great potential in the colorectal cancer research. Genes significantly associated with cancer in microarray studies, were selected as candidate genes in the study. Pooling Internet public microarray data sets can overcome the limitation by the small number of samples in previous studies. Objective: Using public microarray data sets verifies gene expression profiles for colorectal cancer. Methods: Logistic regression analysis was performed, and odds ratios for each gene were determined between CRC and controls. Public microarray datasets of GSE 4107, 4183, 8671, 9348, 10961, 13067, 13294, 13471, 14333, 15960, 17538, and 18105 included 519 cases of adenocarcinoma and 88 controls of normal mucosa, which were used to verify the candidate genes from logistic models and estimated its external generality. Results: A 7-gene model of CPEB4, EIF2S3, MGC20553, MAS4A1, ANXA3, TNFAIP6 and IL2RB was pairwise selected that showed the best results in logistic regression analysis (H-L p=1.000, R2=0.951, AUC=0.999, accuracy=0.968, specificity=0.966 and sensitivity=0.994). Conclusions: A novel gene expression profile was associated with CRC and can potentially be applied to bloodbased detection assays.

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