alexa A General Overview of Adaptive Randomization Design for
ISSN: 2155-6180

Journal of Biometrics & Biostatistics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

A General Overview of Adaptive Randomization Design for Clinical Trials

Jianchang Lin1*, Li-An Lin2 and Serap Sankoh1

1Takeda Pharmaceutical Company Limited, Cambridge, MA, USA

2Merck Research Laboratories, Whitehouse Station, New Jersey , USA

*Corresponding Author:
Jianchang Lin
Takeda Pharmaceutical Company Limited
Cambridge, MA, USA
Tel: +1-617-679-7000
E-mail: [email protected]

Received Date: March 25, 2016; Accepted Date: April 14, 2016; Published Date: April 21, 2016

Citation: Lin J, Lin LA, Sankoh S (2016) A General Overview of Adaptive Randomization Design for Clinical Trials. J Biom Biostat 7:294. doi:10.4172/2155-6180.1000294

Copyright: © 2016 Lin J, et al.This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

With the recent release of FDA draft guidance (2010), adaptive designs, including adaptive randomization (e.g. response-adaptive (RA) randomization) has become popular in clinical trials because of its advantages of flexibility and efficiency gains, which also have the significant ethical advantage of assigning fewer patients to treatment arms with inferior outcomes. In this paper, we presented a general overview of adaptive randomization designs for clinical trials, including Bayesian and frequentist approaches as well as response-adaptive randomization. Examples were used to demonstrate the procedure for design parameters calibration and operating characteristics. Both advantages and disadvantages of adaptive randomization were discussed in the summary from practical perspective of clinical trials.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords