alexa A Histological Study on the Treatment of Acne Scars with Fractional Radiofrequency: Preliminary Findings
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Research Article

A Histological Study on the Treatment of Acne Scars with Fractional Radiofrequency: Preliminary Findings

Tokuya Omi1,2*, Shigeru Sato3, Chikako Kaminaka4,5, Yuki Yamamoto4,5, Seiji Kawana2 and Zenya Naito6

1Department of Dermatology, Queen’s Square Medical Center, Yokohama, Japan

2Department of Dermatology, Nippon Medical School, Tokyo, Japan

3Division of Morphological and Biomolecular Research, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan

4Department of Dermatology, Wakayama Medical University, Wakayama, Japan

5Department of Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Wakayama, Japan

6Departments of Pathology and Integrative Oncological Pathology, Nippon Medical School, Tokyo, Japan

*Corresponding Author:
Tokuya Omi
Department of Dermatology
Queen’s Square Medical Center
2-3-5 Minatomirai, Yokohama, Japan
Tel: +81-45-682-4112
E-mail: [email protected]

Received date: December 19, 2013; Accepted date: January 04, 2014; Published date: January 11, 2014

Citation: Omi T, Sato S, Kaminaka C, Yamamoto Y, Kawana S, et al. (2014) A Histological Study on the Treatment of Acne Scars with Fractional Radiofrequency: Preliminary Findings. J Clin Exp Dermatol Res 5:203. doi: 10.4172/2155-9554.1000203

Copyright: © 2014 Omi T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background and aims: After the inflammatory stage of severe acne vulgaris, atrophic scarring may occur this is problematic to both the patient and surgeon. A variety of treatment techniques including ablative and nonablative lasers have been used, however results have been inconsistent with both over- and under-treatment. Fractional radiofrequency (RF) has recently attracted attention in this field. The present study evaluated changes in the dermal morphology and ultrastructure one month post-fractional RF treatment.

Patients and methods: The study subjects were 4 females and 2 males (Fitzpatrick skin type IV, mean age 39.3 yr) with moderate to severe acne scarring. They were treated with a single session of fractional RF (peak energy level of 25 J). Biopsies were obtained before, immediately after and 1 month after treatment, and examined under both light and transmission electron microscopy.

Results: Before treatment, the dermis in all patients demonstrated dense connective tissue with hyperplasia of elastic fibers with sporadic depositions of elastin. Histological and ultrastructural evaluation at one month after fractional RF treatment revealed remodeling of the dermis, accompanied by elastic fiber remodeling, to give a more normallooking morphology.

Conclusions: Fractional-type RF therapy is promising, not only as a means of treating acne as reported previously, but also in the treatment of acne scars through remodeling of the dermis to replace acne scar-associated morphological and ultrastructural irregularities with a more normal architecture.


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