alexa A Hyperglycemic, Obese and Fast-Weight Losing Adult: A Case Report on Latent Autoimmune Diabetes with Low Anti-Gad65 Titers | OMICS International | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Case Report

A Hyperglycemic, Obese and Fast-Weight Losing Adult: A Case Report on Latent Autoimmune Diabetes with Low Anti-Gad65 Titers

Carmen Suárez1, Carmen Chávez2, Adriana David2, Miguel Aguirre2, Joselyn Rojas2,3, Manuel Velasco4 and Valmore Bermúdez1*

1 Fellow of the Advanced Endocrinology Masters Program, University of Alcalá de Henares, Spain

2 Endocrine and Metabolic Diseases Research Center, The University of Zulia, Venezuela

3 Institute of Clinical Immunology, University of Los Andes, Mérida, Venezuela

4 Hypertension Clinic Unit, Vargas Medicine School, Central University of Venezuela, Venezuela

*Corresponding Author:
Valmore J Bermúdez
The Zulia University, Medicine Faculty
School of Medicine, Endocrine and Metabolic Diseases Research Center
The University of Zulia, Maracaibo, Venezuela
Fax: 58-261-7597279
E-mail: [email protected]

Received date: June 13, 2013; Accepted date: July 10, 2013; Published date: July 16, 2013

Citation: Suárez C, Chávez C, David A, Aguirre M, Rojas J, et al. (2013) A Hyperglycemic, Obese and Fast-Weight Losing Adult: A Case Report on Latent Autoimmune Diabetes with Low Anti-Gad65 Titers. J Diabetes Metab 4:275. doi: 10.4172/2155-6156.1000275

Copyright: © 2013 Suárez C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: Latent Autoimmune Diabetes in Adults (LADA) is an autoimmune endocrine disorder, in which in spite of having positive anti-islet antibodies, the progression to full blown beta cell destruction and insulin insufficiency is slower. This scenario is often mistaken by other types of diabetes and due to this misdiagnosis the initial treatment is often mistaken.

Clinical case: Male subject, 26 years of age, obese at the moment of the first hyperglycemic crisis, with a previous diagnosis of Type 2 Diabetes Mellitus (T2DM) 3 years before arriving to our institution. He refers to have been on oral treatment for his disease with no metabolic control, finally succumbing to polyuria, polydypsia and an important weight loss of 30 kg in the course of 1 year. Family history shows first and second degree history of T2DM. Upon arrival, physical examination showed 140/85 mmHg, BMI 30.31 kg/m2, fasting glycemia 283.90 mg/dL, postpandrial glycemia 306.70 mg/dL, fasting C- peptide 2.0 ng/mL, postprandial C-peptide 3.4 ng/mL, HOMAbcell 12.7%, HOMA2-IR 1.8. A presumptive diagnosis of LADA was made and confirmation was obtained with positive anti-GAD65 titers. Intense insulin therapy was initiated and the patient evolved adequately.

Conclusions: LADA should be suspected in patients whose metabolic parameters decline continuously and severely, even in those who are keeping up with the oral antidiabetics. In this patient, the age of onset, family history of T2DM, unattainable metabolic control, and steep weight loss were important signs in the proper reclassification and aid in the initiation of proper medical treatment.


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