alexa A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism
ISSN: 2165-7890

Autism-Open Access
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Research Article

A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism

Anthony Torres*, Jonna Westover, Michael Benson, Randall Johnson, Annelise Dykes

 

Center for Persons with Disabilities, Utah State University, Logan, Utah, USA

*Corresponding Author:
Torres A
Center for Persons with Disabilities
Utah State University, Logan, Utah, USA
Tel: (435) 797 - 8874
E-mail: [email protected]

Rec date: February 23, 2016; Acc date: March 21, 2016; Pub date: March 28, 2016

Citation: Torres A, Westover J, Benson M, Johnson R, Dykes A (2016) A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism. Autism Open Access 6:171. doi:10.4172/2165-7890.1000171

Copyright: © 2016 Torres A, et al. This is an open - access article distributed under the terms of the Creative Commons Attribution License, which permits nrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

 

Abstract

The killing activity of natural killer cells is largely regulated by the binding of class I human leukocyte antigen cognate ligands to killer cell immunoglobulin - like receptor proteins. The killer cell immunoglobulin - like receptor gene - complex contains genes that activate and others that inhibit the killing state of natural killer cells depending on the binding of specific human leukocyte antigen cognate ligands. It has been suggested in previous publications that activating human leukocyte antigen / killer - cell immunoglobulin - like receptor complexes are increased in people with autism. We present data, which suggests that an activating cB01 / tA01 killer cell immunoglobulin - like receptor gene - content haplotype and the cognate ligand human leukocyte antigen - C1k that activates this haplotype is significantly increased in autism. This is an important observation suggesting that the interaction between two proteins encoded on different chromosomes increases natural killer cell killing in autism

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