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A Local Relapse of Small Cell Neuroendocrine Carcinoma of Larynx.andldquo;The Tortoise and the Hareandrdquo; | OMICS International | Abstract
ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
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Case Report

A Local Relapse of Small Cell Neuroendocrine Carcinoma of Larynx.“The Tortoise and the Hare”

Tebra Mrad Sameh1*, Cherif Mohamed Aziz1, Bouzid Nadia1, Trimeche Mounir2 and Bouaouina Noureddine1

1Radiation Therapy Department, Farhat Hached Sousse Teaching Hospital, Tunisia

2Pathology Department, Farhat Hached Sousse Teaching Hospital, Tunisia

*Corresponding Author:
Tebra Mrad Sameh
Radiation Therapy Department
Farhat Hached Sousse Teaching Hospital, Tunisia
E-mail: [email protected]

Received date: November 01, 2011; Accepted date: April 23, 2012; Published date: April 26, 2012

Citation: Sameh TM, Aziz CM, Nadia B, Mounir T, Noureddine B (2012) A Local Relapse of Small Cell Neuroendocrine Carcinoma of Larynx. “The Tortoise and the Hare”. J Nucl Med Radiat Ther 3:127. doi:10.4172/2155-9619.1000127

Copyright: © 2012 Sameh TM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The primitive Small Cell Neuroendocrine Carcinoma (SCNC) is a rare subtype of neuroendocrine laryngeal tumors which are the second most common laryngeal neoplasm after squamous cell carcinoma. We report a case of SCNC of the larynx occurring in a 35-year-old man, who smokes and drinks alcohol, who presented with dysphonia and dyspnea. On clinical examination there were painless, mobile cervical lymph nodes in addition to gynecomastia. On endoscopy, the lesion was exophytic and involved the whole of the right vocal cord. SCNC diagnosis was based on morphologic and immune-histochemical criteria. Treatment was non-surgical based on sequential chemoradiation therapy. An isolated local relapse was, unexpectedly, the first post therapeutic event, occurring at the end of the first year of follow up and managed by salvage surgery. Metastatic-free survival was 28 months.


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