alexa A Mammalian Cell-based Nanomechanical Biosensor | OMICS International
ISSN: 2155-983X

Journal of Nanomedicine & Biotherapeutic Discovery
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Research Article

A Mammalian Cell-based Nanomechanical Biosensor

Mei-Juan Han, Minghong Li, Wenjian Du, Hai-Feng Ji* and Jun Xi*

Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, United States

*Corresponding Author:
Hai-Feng Ji
Department of Chemistry, Drexel University
3141 Chestnut Street, Philadelphia
Pennsylvania 19104, USA
Tel: 215-895-2648
Fax: 215-895-1265
E-mail: [email protected], [email protected]


Jun Xi
Department of Chemistry, Drexel University
3141 Chestnut Street, Philadelphia
Pennsylvania 19104, USA
Tel: 215-895-2648
Fax: 215-895-1265
E-mail: [email protected]

Received Date: August 17, 2012; Accepted Date: August 29, 2012; Published Date: August 31, 2012

Citation: Han MJ, Li M, Du W, Ji HF, Xi J (2012) A Mammalian Cell-Based Nanomechanical Biosensor. J Nanomed Biotherapeut Discov 2:106. doi: 10.4172/2155-983X.1000106

Copyright: © 2012 Han MJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

As a natural living system, mammalian cells have the ability to respond to various environmental cues in
distinct ways at both the cellular and molecule levels. Such unique ability of the cells can be utilized for the
rapid detection of chemical and biological analytes. In this report, we have demonstrated the feasibility of a novel cell-based biosensor that utilizes a microcantilever to convert a cellular response to a measurable mechanical response. With this innovative approach, we have been able to detect the distinct responses of α-cyclodextrin and methyl-β-cyclodextrin with mammalian cells based on their differential effects on cells. This study has established a foundation for the future development of a highly sensitive sensing platform for environmental, medical, toxicological, and defense applications.

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