alexa A Microemulsion for the Oral Drug Delivery of Pitavastatin | OMICS International
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Research Article

A Microemulsion for the Oral Drug Delivery of Pitavastatin

Evren Gundogdu1*, Yucel Baspinar2, Cinel Koksal2,3, Iskender Ince2 and Ercument Karasulu1,2

1Faculty of Pharmacy, Department of Biopharmaceutics and Pharmacokinetics, Ege University, 35100 Bornova, Izmir, Turkey

2Center for Drug Research and Development and Pharmacokinetic Applications, Ege University, 35100, Izmir, Turkey

3Faculty of Science, Department of Biology, Ege University, 35100 Bornova, Izmir, Turkey

*Corresponding Author:
Evren Gundogdu
Faculty Of Pharmacy
Department Of Biopharmaceutics and Pharmacokinetics
Ege University, 35100 Bornova, Izmir, Turkey
E-mail: [email protected]

Received date: January 11, 2013; Accepted date: January 28, 2013; Published date: January 30, 2013

Citation: Gundogdu E, Baspinar Y, Koksal C, Ince I, Karasulu E (2013) A Microemulsion for the Oral Drug Delivery of Pitavastatin. Pharmaceut Anal Acta 4:209. doi: 10.4172/2153-2435.1000209

Copyright: © 2013 Gundogdu E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The aim of this study was to evaluate the potential application of a microemulsion as an oral drug delivery system for pitavastatin and to compare its in vitro cytotoxicity with a pitavastatin solution. The here developed water in oil (w/o) microemulsion system was optimized by using pseudo ternary phase diagrams, composed of span 80, Lutrol F 127, isopropyl alcohol, oleic acid and distilled water. This microemulsion was characterized according to its phase behavior, droplet size, viscosity, conductivity, refractive index and polydispersity index. The final concentration of pitavastatin in the microemulsion was 1 mg/ml. Moreover, the in vitro cytotoxicity studies were performed with Caco-2 and MCF-7 cell lines for the microemulsion and the pitavastatin solution. The in vitro cytotoxicity studies revealed no cytotoxic effect on Caco-2 and MCF-7 cells for both microemulsions, with and without pitavastatin and for the pitavastatin solutions. In conclusion, the microemulsion formulation may be used as an effective and alternative drug delivery system for the hyperlipidemic oral therapy with pitavastatin.

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