A Multi-Component Reaction to 6-Aminothiouracils: Synthesis, Mechanistic Study and Antitumor ActivityRadini IAM*
Department of Chemistry, Faculty of Science, Jazan University, Jazan, 2097, Saudi Arabia
- *Corresponding Author:
- Radini IAM
Chemistry Department, Faculty of Science
Jazan University, Jazan
2097, Saudi Arabia
Tel: +966 0566444196
E-mail: [email protected]
Received date: July 21, 2016; Accepted date: August 10, 2016; Published date: August 18, 2016
Citation: Radini IAM (2016) A Multi-Component Reaction to 6-Aminothiouracils: Synthesis, Mechanistic Study and Antitumor Activity. Chemo Open Access 5:212. doi: 10.4172/2167-7700.1000212
Copyright: © 2016 Radini IAM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present work deals with design, synthesis, mechanistic study and biological evaluation of novel, diverse compounds as potential inhibitors of cyclin-dependent kinase 2 (CDK2). Multi-complex-based method has been suggested to generate a comprehensive pharmacophore map of cyclin-dependent kinase 2 (CDK2) based on a collection of 13 crystal structures of human CDK2 inhibitor complex. The proposed chromeno [4',3':4,5] N pyrido [2,3-d] pyrimidine-1,7-dione derivatives were prepared via a multicomponent reaction of 6-aminothiouracil with salicylic aldehyde and acetylacetic ester. The elucidation of the reaction mechanism was investigated and was confirmed by synthetic and spectroscopic methods. All the newly synthesized compounds were tested as CDK2, as antitumor agents and all of them were found to be active.