alexa A New Approach to Drug Therapy: Fc-Fusion Technology
ISSN: 2167-1079

Primary Healthcare: Open Access
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Review Article

A New Approach to Drug Therapy: Fc-Fusion Technology

Valeria P1*, Chrisanthi AK2, Luis-Emilio GP2 and Wolfgang G3

1Eli lilly and Company, Neuilly-sur-Seine, France

2Eli lilly and Company, Indianapolis, IN, USA

3Eli lilly and Company, San Diego, CA, USA

*Corresponding Author:
Valeria P
Eli lilly and Company, Neuilly-sur-Seine, France
Tel: + 33 (0)1 55 49 32 20
Fax: + 33 (0)1 55 49 36 03
E-mail: pechtner_ [email protected]

Received date: December 16, 2016; Accepted date: January 24, 2017; Published date: January 31, 2017

Citation: Valeria P, Chrisanthi AK, Luis-Emilio GP, Wolfgang G (2017) A New Approach to Drug Therapy: Fc-Fusion Technology. Prim Health Care 7:255. doi:10.4172/2167-1079.1000255

Copyright: © 2017 Valeria P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Fc-fusion proteins have been successfully implemented in the treatment of many diseases. Advances in engineering and design of these therapeutic proteins have helped prolong the drug half-life, which in turn allows for longer dosing intervals (i.e. weekly or bi-weekly administration) and, thus, may improve patient adherence in a real world setting. In this review, we provide a brief summary of half-life extension technologies. Here, we focus on IgG-Fc fusion and the key roles that the Fc fragment plays in both physiology and drug therapy, and the potential to elicit immune responses in humans. This review provides examples of various recombinant Fc-fusion protein drugs, including, etanercept (Enbrel®) for the treatment of various forms of arthritis, aflibercept (Eylea®), for the treatment of neovascular age-related macular degeneration and dulaglutide (Trulicity™) for the treatment of type 2 diabetes. All of these fusion proteins can be administered at least weekly. Overall, Fc-fusion proteins have proven to be a successful alternative to improve pharmacological properties of therapeutic drugs, with more convenient utilization in the real world and with low immunogenic potential.


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